Veiga Diogo, Peralta Miguel, Gouveia Élvio R, Nascimento Marcelo de Maio, Carvalho Laura, Encantado Jorge, Marques Adilson
Centro Interdisciplinar de Performance Humana, (CIPER) Faculdade de Motricidade Humana, Universidade de Lisboa, 1499-002 Cruz-Quebrada, Portugal.
Instituto de Saúde Ambiental (ISAMB), Faculdade de Medicina, Universidade de Lisboa, 1649-026 Lisboa, Portugal.
Geriatrics (Basel). 2024 Mar 12;9(2):36. doi: 10.3390/geriatrics9020036.
Depression and cardiovascular diseases are two main health conditions contributing to the global disease burden. Several studies indicate a reciprocal association between them. It is still unclear how changes in overall muscle strength may impact this association. This study aimed to analyse how muscular strength moderates the relationship between cardiovascular events and depressive symptoms among middle-aged and older adults.
Wave 8 of the population-based Survey of Health, Ageing, and Retirement in Europe (2019/2020) cross-sectional data, which included 41,666 participants (17,986 men) with a mean age of 70.65 (9.1) years old, was examined. Grip strength was measured twice on each hand using a dynamometer. The 12-item EURO-D scale was employed to gauge depressive symptoms.
Grip strength negatively moderates the link between cardiovascular events and depressive symptoms (male: B = -0.03, 95% CI = -0.04, -0.03; female: B = -0.06, 95% CI = -0.06, -0.05). Additionally, the grip strength moderation values in the significant zone for males and females were less than 63.2 kg and 48.3 kg, respectively.
Muscular strength modifies depressive symptoms and lessens their correlation with cardiovascular diseases. Muscle-strengthening activities could be incorporated into primary and secondary preventive strategies to reduce the burden of depression in people with CVD.
抑郁症和心血管疾病是导致全球疾病负担的两个主要健康问题。多项研究表明它们之间存在相互关联。目前尚不清楚整体肌肉力量的变化如何影响这种关联。本研究旨在分析肌肉力量如何调节中老年人心血管事件与抑郁症状之间的关系。
对基于人群的欧洲健康、老龄化和退休调查（2019/2020）第8波横断面数据进行了分析，该数据包括41666名参与者（17986名男性），平均年龄为70.65（9.1）岁。使用握力计对每只手的握力进行两次测量。采用12项欧洲抑郁量表（EURO-D）来评估抑郁症状。
握力对心血管事件与抑郁症状之间的联系具有负向调节作用（男性：B = -0.03，95%置信区间 = -0.04，-0.03；女性：B = -0.06，95%置信区间 = -0.06，-0.05）。此外，男性和女性在显著区域的握力调节值分别小于63.2千克和48.3千克。
肌肉力量可改善抑郁症状，并减轻其与心血管疾病的相关性。可将肌肉强化活动纳入一级和二级预防策略，以减轻心血管疾病患者的抑郁负担。
