I 组内含子：结构、剪接及其在医学真菌学中的应用。

Group I introns: Structure, splicing and their applications in medical mycology.

作者信息

Gomes Ronald Muryellison Oliveira da Silva, Silva Kássia Jéssica Galdino da, Theodoro Raquel Cordeiro

机构信息

Universidade Federal do Rio Grande do Norte, Instituto de Medicina Tropical do Rio Grande do Norte, Natal, RN, Brazil.

Universidade Federal do Rio Grande do Norte, Centro de Biociências, Departamento de Biologia Celular de Genética, Natal, RN, Brazil.

出版信息

Genet Mol Biol. 2024 Mar 25;47Suppl 1(Suppl 1):e20230228. doi: 10.1590/1678-4685-GMB-2023-0228. eCollection 2024.

DOI:10.1590/1678-4685-GMB-2023-0228

PMID:38525907

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10964413/

Abstract

Group I introns are small RNAs (250-500 nt) capable of catalyzing their own splicing from the precursor RNA. They are widely distributed across the tree of life and have intricate relationships with their host genomes. In this work, we review its basic structure, self-splicing and its mechanisms of gene mobility. As they are widely found in unicellular eukaryotes, especially fungi, we gathered information regarding their possible impact on the physiology of fungal cells and the possible application of these introns in medical mycology.

摘要

I 组内含子是能够催化自身从前体RNA中剪接出来的小RNA（250 - 500个核苷酸）。它们广泛分布于整个生命树中，并且与其宿主基因组有着复杂的关系。在这项工作中，我们综述了其基本结构、自我剪接以及基因移动机制。由于它们在单细胞真核生物尤其是真菌中广泛存在，我们收集了有关它们对真菌细胞生理学可能产生的影响以及这些内含子在医学真菌学中可能应用的信息。