光氧化还原催化的α-三氟甲基烯烃与酰氯的酰氯化反应及其作为β-三氟甲基烯酮的掩蔽合成方法的应用
Photoredox-Catalyzed Acylchlorination of α-CF Alkenes with Acyl Chloride and Application as Masked Access to β-CF-enones.
作者信息
Zhou Youkang, Jiang Qi, Cheng Yangyang, Hu Mingyou, Duan Xin-Hua, Liu Le
机构信息
School of Chemistry, Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an 710049, China.
Key Laboratory for Tumor Precision Medicine of Shaanxi Province and Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, China.
出版信息
Org Lett. 2024 Apr 5;26(13):2656-2661. doi: 10.1021/acs.orglett.4c00830. Epub 2024 Mar 25.
We disclose a photocatalytic strategy that simultaneously addresses the construction of trifluoromethylated quaternary carbon centers and the preparation of β-CF-enones through radical difunctionalization of α-CF alkenes with acyl chlorides. This method is characterized by its broad functional group compatibility, high efficiency, and atom economy. The versatility of this transformation is poised to broaden the applications of α-CF alkenes, providing new pathways for the rapid assembly of structurally diverse fluorinated compounds.
我们公开了一种光催化策略，该策略通过α-三氟甲基烯烃与酰氯的自由基双官能化反应，同时实现了三氟甲基化季碳中心的构建以及β-三氟甲基烯酮的制备。该方法具有官能团兼容性广、效率高和原子经济性好的特点。这种转化反应的多功能性有望拓宽α-三氟甲基烯烃的应用范围，为结构多样的含氟化合物的快速组装提供新途径。
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