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Management of enzyme de-induction in a woman with HIV on methadone maintenance switched from nevirapine- to bictegravir-based antiretroviral regimen.

作者信息

Cattaneo Dario, Giacomelli Andrea, Casalini Giacomo, Ridolfo Anna Lisa, Gervasoni Cristina

机构信息

Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, via GB Grassi 74, 20157, Milan, Italy.

Gestione Ambulatoriale Politerapie (GAP) Outpatient Clinic, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.

出版信息

Eur J Clin Pharmacol. 2024 Jul;80(7):1105-1106. doi: 10.1007/s00228-024-03681-x. Epub 2024 Mar 25.

DOI:10.1007/s00228-024-03681-x
PMID:38526747
Abstract
摘要

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Management of enzyme de-induction in a woman with HIV on methadone maintenance switched from nevirapine- to bictegravir-based antiretroviral regimen.一名接受美沙酮维持治疗的感染艾滋病毒女性，其抗逆转录病毒治疗方案从基于奈韦拉平转换为基于比克替拉韦，酶诱导的管理。
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引用本文的文献

1
Delayed psychotropic toxicity after switching from nevirapine to bictegravir: the role of enzyme de-induction in people with HIV and polypharmacy.从奈韦拉平转换为比克替拉韦后的迟发性精神药物毒性：酶去诱导在HIV感染者和多药治疗中的作用
Eur J Clin Pharmacol. 2025 Sep;81(9):1375-1376. doi: 10.1007/s00228-025-03873-z. Epub 2025 Jul 1.

本文引用的文献

1
Management of Drug Interactions with Inducers: Onset and Disappearance of Induction on Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyltransferase 1A1 Substrates.药物相互作用管理：细胞色素 P450 3A4 和尿苷二磷酸葡萄糖醛酸转移酶 1A1 底物诱导作用的起始和消失。
Eur J Drug Metab Pharmacokinet. 2023 Jul;48(4):353-362. doi: 10.1007/s13318-023-00833-9. Epub 2023 Jun 6.
2
Comparative Clinical Pharmacokinetics and Pharmacodynamics of HIV-1 Integrase Strand Transfer Inhibitors: An Updated Review.HIV-1 整合酶链转移抑制剂的比较临床药代动力学和药效学：更新综述。
Clin Pharmacokinet. 2020 Sep;59(9):1085-1107. doi: 10.1007/s40262-020-00898-8.
3
Nevirapine plasma concentrations are still detectable after more than 2 weeks in the majority of women receiving single-dose nevirapine: implications for intervention studies.
在大多数接受单剂量奈韦拉平的女性中，超过2周后血浆中的奈韦拉平浓度仍可检测到：对干预研究的启示。
J Acquir Immune Defic Syndr. 2005 Aug 1;39(4):419-21. doi: 10.1097/01.qai.0000167154.37357.f9.
4
Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert.接受美沙酮维持治疗方案的HIV患者中奈韦拉平诱发的戒断症状：一则警示
AIDS. 1999 May 28;13(8):1004-5. doi: 10.1097/00002030-199905280-00025.
5
Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone.奈韦拉平在接受美沙酮治疗的HIV感染注射吸毒者中引发了阿片类药物戒断反应。
AIDS. 1999 May 28;13(8):957-62. doi: 10.1097/00002030-199905280-00012.
6
Methadone withdrawal when starting an antiretroviral regimen including nevirapine.开始使用包括奈韦拉平在内的抗逆转录病毒治疗方案时的美沙酮戒断反应。
Pharmacotherapy. 1999 Apr;19(4):471-2. doi: 10.1592/phco.19.6.471.31046.
7
Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes.细胞色素P450 3A4酶在人肝微粒体中美沙酮N-去甲基化过程中的作用。
Chem Res Toxicol. 1996 Mar;9(2):365-73. doi: 10.1021/tx950116m.