评估鼻咽癌患者的营养不良：新营养评估工具的开发和验证的诊断方案。

Assessing malnutrition in patients with nasopharyngeal carcinoma: Diagnostic protocol for the development and validation of a new nutritional assessment tool.

机构信息

Nursing College of Guangxi Medical University, Nanning, Guangxi, China.

Department of Nursing, Universiti Putra Malaysia, Selangor, Serdang, Malaysia.

出版信息

PLoS One. 2024 Mar 25;19(3):e0300067. doi: 10.1371/journal.pone.0300067. eCollection 2024.

DOI:10.1371/journal.pone.0300067

PMID:38527072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10962806/

Abstract

INTRODUCTION

There is currently no gold standard or specific nutritional assessment tool to assess malnutrition in patients with nasopharyngeal carcinoma (NPC). Our study aims to develop a new nutritional assessment tool for NPC patients.

METHODS AND ANALYSIS

NPC patients will be required to complete a risk factor questionnaire after obtaining their informed consent. The risk factor questionnaire will be used to collect potential risk factors for malnutrition. Univariate and multivariate logistic regression analyses will be used to identify risk factors for malnutrition. A new nutritional assessment tool will be developed based on risk factors. The new tool's performance will be assessed by calibration and discrimination. The bootstrapping will be used for internal validation of the new tool. In addition, external validation will be performed by recruiting NPC patients from another hospital.

DISCUSSION

If the new tool is validated to be effective, it will potentially save medical staff time in assessing malnutrition and improve their work efficiency. Additionally, it may reduce the incidence of malnutrition and its adverse consequences.

STRENGTHS AND LIMITATIONS OF THIS STUDY

The study will comprehensively analyze demographic data, disease status, physical examination, and blood sampling to identify risk factors for malnutrition. Furthermore, the new tool will be systematically evaluated, and validated to determine their effectiveness. However, the restricted geographical range may limit the generalizability of the results to other ethnicities. Additionally, the study does not analyze subjective indicators such as psychology.

ETHICS AND DISSEMINATION

The ethical approval was granted by the Ethical Committee of the First Affiliated Hospital of Guangxi Medical University (NO. 2022-KT-GUI WEI-005) and the Second Affiliated Hospital of Guangxi Medical University (NO. 2022-KY-0752).

CLINICAL TRIAL REGISTRATION NUMBER

ChiCTR2300071550.

摘要

简介

目前尚无金标准或特定的营养评估工具来评估鼻咽癌（NPC）患者的营养不良。我们的研究旨在为 NPC 患者开发一种新的营养评估工具。

方法与分析

在获得患者知情同意后，要求 NPC 患者完成一份危险因素问卷。危险因素问卷将用于收集营养不良的潜在危险因素。将进行单因素和多因素逻辑回归分析，以确定营养不良的危险因素。将根据危险因素开发新的营养评估工具。新工具的性能将通过校准和区分进行评估。将使用自举法对新工具进行内部验证。此外，将通过招募另一家医院的 NPC 患者来进行外部验证。