Sarah Lawrence College.
National Institute of Mental Health.
J Cogn Neurosci. 2024 Dec 1;36(12):2687-2696. doi: 10.1162/jocn_a_02144.
This special focus article was prepared to honor the memory of our National Institutes of Health colleague, friend, and mentor Leslie G. Ungerleider, who passed away in December 2020, and is based on a presentation given at a symposium held in her honor at the National Institutes of Health in September 2022. In this article, we describe an extension of Leslie Ungerleider's influential work on the object analyzer pathway in which the inferior temporal visual cortex interacts with the amygdala, and then discuss a broader role for the amygdala in stimulus-outcome associative learning in humans and nonhuman primates. We summarize extant data from our and others' laboratories regarding two distinct frontal-amygdala circuits that subserve nonsocial and social valuation processes. Both neuropsychological and neurophysiological data suggest a role for the OFC in nonsocial valuation and the ACC in social valuation. More recent evidence supports the possibility that the amygdala functions in conjunction with these frontal regions to subserve these distinct, complex valuation processes. We emphasize the dynamic nature of valuation processes and advocate for additional research on amygdala-frontal interactions in these domains.
这篇专题文章是为了纪念我们美国国立卫生研究院的同事、朋友和导师 Leslie G. Ungerleider 而撰写的，她于 2020 年 12 月去世。这篇文章基于 2022 年 9 月在国立卫生研究院为纪念她而举行的专题研讨会上的演讲。在本文中，我们描述了 Leslie Ungerleider 关于颞下回视觉皮层与杏仁核相互作用的对象分析途径的有影响力的工作的扩展，并进一步讨论了杏仁核在人类和非人类灵长类动物的刺激-结果联想学习中的更广泛作用。我们总结了来自我们和其他实验室的关于两个不同的额-杏仁核回路的现有数据，这些回路分别支持非社会性和社会性价值过程。神经心理学和神经生理学数据都表明，OFC 在非社会性价值中起作用，而 ACC 在社会性价值中起作用。最近的证据支持了杏仁核与这些额叶区域共同作用以支持这些不同的、复杂的价值过程的可能性。我们强调了价值过程的动态性质，并主张在这些领域进一步研究杏仁核-额叶相互作用。
