Reply to Eichbichler et al.: Phase separation boosts HECT E3-mediated polyubiquitination.
作者信息
Zhu Kang, Li Jingyu, Wen Wenyu
机构信息
Department of Neurosurgery, Huashan Hospital, The Shanghai Key Laboratory of Medical Epigenetics, State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
出版信息
Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2403169121. doi: 10.1073/pnas.2403169121. Epub 2024 Mar 25.
Abstract
摘要
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Reply to Eichbichler et al.: Phase separation boosts HECT E3-mediated polyubiquitination.对艾希比希勒等人的回复：相分离增强了HECT E3介导的多聚泛素化。
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本文引用的文献
1
Phase separation promotes the activity of HECT E3 ligases-A word of caution.相分离促进HECT E3连接酶的活性——一则警示
Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2402551121. doi: 10.1073/pnas.2402551121. Epub 2024 Mar 25.
2
Feedback regulation of ubiquitination and phase separation of HECT E3 ligases.HECT E3 连接酶泛素化和相分离的反馈调节。
Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2302478120. doi: 10.1073/pnas.2302478120. Epub 2023 Aug 7.
3
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment.相分离隔间中酶促速率增加的机制剖析。
Nat Chem Biol. 2021 Jun;17(6):693-702. doi: 10.1038/s41589-021-00801-x. Epub 2021 May 25.
4
1,6-Hexanediol, commonly used to dissolve liquid-liquid phase separated condensates, directly impairs kinase and phosphatase activities.1,6-己二醇，通常用于溶解液-液相分离的冷凝物，直接损害激酶和磷酸酶的活性。
J Biol Chem. 2021 Jan-Jun;296:100260. doi: 10.1016/j.jbc.2021.100260. Epub 2021 Jan 8.
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