Department of Restorative Dental Science, College of Dentistry, King Khalid University Abha, Abha, Saudi Arabia.
Department of Oral and Maxillofacial Surgery, King Khalid University College of Dentistry, Abha, Saudi Arabia.
J Oral Rehabil. 2024 Jul;51(7):1236-1249. doi: 10.1111/joor.13681. Epub 2024 Mar 25.
Obstructive sleep apnoea syndrome (OSAS) has garnered increasing attention in recent years due to its potential association with cancer. This systematic review and meta-analysis aimed to assess the prevalence of OSAS in cancer patients through a comprehensive analysis of existing literature.
This systematic review and meta-analysis, conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, aimed to evaluate the prevalence of OSAS in cancer patients. A comprehensive search of electronic databases was performed to identify relevant studies published up to September 2021. Eligible studies reporting on the prevalence of OSAS in cancer patients, encompassing various study designs, were included in the analysis. Pooled estimates of the odds ratios (OR) with 95% confidence intervals (CIs) were calculated using a random effects model. Heterogeneity among the studies was assessed using the I statistic.
Seventeen studies fulfilled the inclusion criteria and were subsequently included in the review. The prevalence of OSAS in cancer patients was estimated to have an overall OR of 0.80 (95% CI: 0.75-0.85). In comparison with non-cancer patients, cancer patients had a statistically significant greater risk of OSAS, as indicated by the total estimated RR for the prevalence of OSAS in cancer patients, which was 0.89 (95% CI: 0.86-0.92). Nonetheless, there was a significant amount of heterogeneity (I = 96%) among the studies.
The overall data analysed in this review indicates that patients with cancer had far reduced likelihood of developing OSAS than individuals without cancer. However, the significant variation across the included studies highlights the need for additional investigation to fully clarify the complex association between OSAS and cancer incidence. These results emphasise how critical it is to identify OSAS as a possible comorbidity in cancer patients, one that should be taken into account for clinical management and ongoing research.
阻塞性睡眠呼吸暂停综合征（OSAS）近年来受到越来越多的关注，因为它可能与癌症有关。本系统评价和荟萃分析旨在通过综合分析现有文献来评估癌症患者中 OSAS 的患病率。
本系统评价和荟萃分析按照系统评价和荟萃分析的首选报告项目（PRISMA）协议进行，旨在评估癌症患者中 OSAS 的患病率。对截至 2021 年 9 月发表的相关研究进行了全面的电子数据库搜索。纳入分析的研究报告了各种研究设计中癌症患者 OSAS 的患病率。使用随机效应模型计算合并的优势比（OR）及其 95%置信区间（CI）。使用 I 统计量评估研究之间的异质性。
17 项研究符合纳入标准，随后被纳入综述。癌症患者 OSAS 的患病率估计总体 OR 为 0.80（95%CI：0.75-0.85）。与非癌症患者相比，癌症患者发生 OSAS 的风险显著增加，这表明癌症患者 OSAS 患病率的总估计 RR 为 0.89（95%CI：0.86-0.92）。然而，研究之间存在显著的异质性（I=96%）。
本综述分析的总体数据表明，癌症患者发生 OSAS 的可能性远低于非癌症患者。然而，纳入研究之间的显著差异突出表明需要进一步调查以充分阐明 OSAS 与癌症发病率之间的复杂关联。这些结果强调了在癌症患者中识别 OSAS 作为一种可能的合并症的重要性，这应该在临床管理和正在进行的研究中得到考虑。
