Lee Ji-Ho, Hong Se Hwa, Yu Iseul, Chang Min-Seok, Park Sunmin, Lee Seok Jeong, Kim Sang-Ha
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Department of Biostatistics, Yonsei University Wonju College of Medicine, Wonju, Korea.
Allergy Asthma Immunol Res. 2024 Mar;16(2):168-178. doi: 10.4168/aair.2024.16.2.168.
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of vasculitis with multiorgan involvement. The incidence and prevalence of EGPA vary geographically and ethnically. This study investigated the incidence, prevalence, and mortality of EGPA in a nationwide population-based cohort in Korea.
This retrospective cohort study used data from the National Health Insurance database that covers almost all Korean residents. EGPA was identified using relevant diagnostic codes from 2007 to 2018. Newly diagnosed EGPA cases since 2007 and patients who visited outpatient clinics for EGPA at least three times were included. Age- and sex-adjusted standardized incidence and prevalence rates were analyzed.
A total of 843 patients with EGPA were identified. The mean annual standardized incidence between 2007 and 2018 was 1.2 (per 1,000,000 individuals). The incidence of EGPA has increased from 1.1 (per 1,000,000 individuals) in 2007 to 1.6 (per 1,000,000 individuals) in 2017. The standardized prevalence of EGPA has increased from 1.1(per 1,000,000 individuals) in 2007 to 11.2 (per 1,000,000 individuals) in 2018. The incidence and prevalence of EGPA were higher in women than in men. The standardized mortality rate was 1.61 (95% confidence interval [CI], 1.34-1.93) in total population, 1.59 (95% CI, 1.23-2.02) in males, and 1.63 (95% CI, 1.22-2.13) in females.
The incidence of EGPA has increased over the past decade. Incidence and prevalence rates were higher in females than in males. The overall mortality rate associated with EGPA was higher than that in the general population.
嗜酸性肉芽肿性多血管炎（EGPA）是一种累及多器官的罕见血管炎形式。EGPA的发病率和患病率因地域和种族而异。本研究调查了韩国全国基于人群的队列中EGPA的发病率、患病率和死亡率。
这项回顾性队列研究使用了来自覆盖几乎所有韩国居民的国民健康保险数据库的数据。通过2007年至2018年的相关诊断编码确定EGPA。纳入2007年以来新诊断的EGPA病例以及至少三次到门诊就诊的EGPA患者。分析了年龄和性别调整后的标准化发病率和患病率。
共识别出843例EGPA患者。2007年至2018年的年均标准化发病率为1.2（每100万人）。EGPA的发病率从2007年的1.1（每100万人）增加到2017年的1.6（每100万人）。EGPA的标准化患病率从2007年的1.1（每100万人）增加到2018年的11.2（每100万人）。EGPA的发病率和患病率女性高于男性。总人群的标准化死亡率为1.61（95%置信区间[CI]，1.34 - 1.93），男性为1.59（95%CI，1.23 - 2.02），女性为1.63（95%CI，1.22 - 2.13）。
在过去十年中，EGPA的发病率有所增加。发病率和患病率女性高于男性。与EGPA相关的总体死亡率高于一般人群。
