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伪装成弥漫性斑秃的弥漫性扁平苔藓性毛发角化病

Diffuse Lichen Planopilaris Masquerading as Diffuse Alopecia Areata.

作者信息

Yoo Li Jie Helena, Meah Nekma, Wall Dmitri, McDonald Ian

机构信息

Department of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland.

Mersey and West Lancashire Teaching Hospitals NHS Trust, St Helens, UK.

出版信息

Case Rep Dermatol. 2024 Mar 25;16(1):83-87. doi: 10.1159/000538064. eCollection 2024 Jan-Dec.

DOI:10.1159/000538064
PMID:38529513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10963056/
Abstract

INTRODUCTION

Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia that represents a form of follicular lichen planus.

CASE PRESENTATION

We describe a case of coexisting diffuse LPP and female pattern hair loss masquerading as diffuse alopecia areata in a 32-year-old female.

DISCUSSION

In complex cases such as this, dermoscopy-guided vertical and horizontal biopsies from androgen sensitive and insensitive areas are helpful in increasing diagnostic yield. Prompt initiation of treatment is key to halting disease progression. Long-term follow-up is important as resolution of clinical signs does not always correlate with the absence of disease progression.

摘要

引言

扁平苔藓性毛发角化病（LPP）是一种原发性淋巴细胞性瘢痕性脱发，是毛囊扁平苔藓的一种形式。

病例报告

我们描述了一例32岁女性患者，其同时存在弥漫性LPP和伪装成弥漫性斑秃的女性型脱发。

讨论

在这样的复杂病例中，在雄激素敏感和不敏感区域进行皮肤镜引导下的垂直和水平活检有助于提高诊断率。及时开始治疗是阻止疾病进展的关键。长期随访很重要，因为临床症状的消退并不总是与疾病进展的停止相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/10963056/f51a390bfb77/cde-2024-0016-0001-538064_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/10963056/083c20bdd939/cde-2024-0016-0001-538064_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/10963056/f51a390bfb77/cde-2024-0016-0001-538064_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/10963056/083c20bdd939/cde-2024-0016-0001-538064_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/10963056/f51a390bfb77/cde-2024-0016-0001-538064_F02.jpg

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本文引用的文献

1
Focal and diffuse fibrosing alopecias: Classical lichen planopilaris, frontal fibrosing alopecia, fibrosing alopecia with a pattern distribution, cicatricial pattern hair loss, and lichen planopilaris diffuse pattern.局限性和弥漫性纤维化性秃发：经典扁平苔藓样毛发扁平苔藓、额部纤维化性秃发、具有模式分布的纤维化性秃发、瘢痕性脱发模式以及扁平苔藓样毛发扁平苔藓弥漫性模式。
JAAD Case Rep. 2020 Apr 29;6(5):403-410. doi: 10.1016/j.jdcr.2020.02.036. eCollection 2020 May.
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Fibrosing alopecia in a pattern distribution.纤维化脱发，呈图案状分布。
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Diffuse variants of scalp lichen planopilaris: Clinical, trichoscopic, and histopathologic features of 40 patients.
头皮扁平苔藓弥漫性变异型：40 例患者的临床、毛发镜和组织病理学特征。
J Am Acad Dermatol. 2020 Dec;83(6):1659-1667. doi: 10.1016/j.jaad.2019.11.006. Epub 2019 Nov 9.
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Lichen planopilaris: retrospective study on the characteristics and treatment of 291 patients.扁平苔藓样糠疹：291 例患者特征和治疗的回顾性研究。
J Dermatolog Treat. 2019 Sep;30(6):598-604. doi: 10.1080/09546634.2018.1542480. Epub 2019 Jan 4.
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Utility of horizontal and vertical sections of scalp biopsies in various forms of primary alopecias.头皮活检水平及垂直切片在各种原发性脱发形式中的应用价值。
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A case series of 46 patients with lichen planopilaris: Demographics, clinical evaluation, and treatment experience.46例扁平苔藓样毛发角化病患者的病例系列：人口统计学、临床评估及治疗经验
J Dermatolog Treat. 2015 Jun;26(3):275-9. doi: 10.3109/09546634.2014.933165. Epub 2014 Jul 1.
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Frontal fibrosing alopecia: a multicenter review of 355 patients.额部纤维性脱发：355 例患者的多中心回顾。
J Am Acad Dermatol. 2014 Apr;70(4):670-678. doi: 10.1016/j.jaad.2013.12.003. Epub 2014 Feb 5.
8
Dermoscopy guided scalp biopsy in cicatricial alopecia.皮肤镜引导头皮活检在瘢痕性脱发中的应用。
J Eur Acad Dermatol Venereol. 2013 Oct;27(10):1299-303. doi: 10.1111/j.1468-3083.2012.04530.x. Epub 2012 Mar 26.
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