Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Epidemiologic Research & Methods, LLC, Southport, NC, USA.
J Med Virol. 2024 Mar;96(3):e29525. doi: 10.1002/jmv.29525.
Seroprevalence data for cytomegalovirus (CMV), a widespread virus causing lifelong infection, vary widely, and contemporary data from the United States (US) and Canada are limited. Utilizing a modeling approach based on a literature review (conducted August, 2022) of data published since 2005, we determine age-, sex-, and country-specific CMV seroprevalence in the general US and Canadian populations. Sex-specific data were extracted by age categories, and a random-effects meta-regression model was used to fit the reported data (incorporating splines for the US). Seven studies reported US CMV seroprevalence (both sexes, aged 1‒89 years); all used National Health and Nutrition Examination Survey data. Due to limited population-based studies, Canadian estimates were modeled using other limited country data. In both countries, modeled seroprevalence estimates increased with age and were higher in females versus males (US: 49.0% vs. 41.6% at 18‒19 years; 61.5% vs. 50.0% at 38‒39 years; Canada: 23.7% vs. 13.7% at 18‒19 years; 32.6% vs. 22.6% at 38‒39 years). Notably, by young adulthood, one-half of US and one-quarter of Canadian females have acquired CMV. The observed differences in CMV seroprevalence in the US and Canada may partially reflect variations in general population characteristics.
巨细胞病毒（CMV）血清流行率数据差异很大，CMV 是一种广泛存在的病毒，可导致终身感染。目前美国（US）和加拿大的当代数据有限。我们利用基于文献回顾（2022 年 8 月进行）的建模方法，确定了普通美国和加拿大人群中 CMV 的年龄、性别和国家特异性血清流行率。按年龄类别提取了性别特异性数据，并使用随机效应荟萃回归模型拟合报告数据（纳入了美国的样条）。有 7 项研究报告了美国 CMV 血清流行率（男女，年龄 1-89 岁）；均使用了国家健康和营养检查调查数据。由于基于人群的研究有限，因此使用其他有限的国家数据对加拿大的估计进行了建模。在这两个国家，模型化的血清流行率估计值随年龄增长而增加，女性高于男性（美国：18-19 岁时为 49.0%比 41.6%；38-39 岁时为 61.5%比 50.0%；加拿大：18-19 岁时为 23.7%比 13.7%；38-39 岁时为 32.6%比 22.6%）。值得注意的是，在年轻成年时，一半的美国女性和四分之一的加拿大女性已经感染了 CMV。美国和加拿大 CMV 血清流行率的差异可能部分反映了一般人群特征的差异。
