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How do small quantities of cartilage sodium channels play a significant role in osteoarthritis?

作者信息

Kong Xiaohong, Liu Chuan-Ju

机构信息

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA.

出版信息

Clin Transl Med. 2024 Mar;14(3):e1634. doi: 10.1002/ctm2.1634.

DOI:10.1002/ctm2.1634

PMID:38530147

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10964914/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b18/10964914/f16adcdba640/CTM2-14-e1634-g001.jpg

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本文引用的文献

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Ann Rheum Dis. 2021 Dec;80(12):1615-1627. doi: 10.1136/annrheumdis-2021-220000. Epub 2021 Jul 5.

TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity.

J Clin Invest. 2021 Aug 16;131(16). doi: 10.1172/JCI144016.

Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling.

Arthritis Rheumatol. 2016 Dec;68(12):2845-2856. doi: 10.1002/art.39816.

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling.

Ann Rheum Dis. 2015 Dec;74(12):2244-2253. doi: 10.1136/annrheumdis-2014-205779. Epub 2014 Aug 28.

Progranulin: a growth factor, a novel TNFR ligand and a drug target.

Pharmacol Ther. 2012 Jan;133(1):124-32. doi: 10.1016/j.pharmthera.2011.10.003. Epub 2011 Oct 8.

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10.

The role of ADAMTSs in arthritis.

Protein Cell. 2010 Jan;1(1):33-47. doi: 10.1007/s13238-010-0002-5. Epub 2010 Feb 7.

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How do small quantities of cartilage sodium channels play a significant role in osteoarthritis?

作者信息

Kong Xiaohong, Liu Chuan-Ju

机构信息

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA.

出版信息

Clin Transl Med. 2024 Mar;14(3):e1634. doi: 10.1002/ctm2.1634.

DOI:10.1002/ctm2.1634

PMID:38530147

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10964914/

Abstract

摘要

相似文献

How do small quantities of cartilage sodium channels play a significant role in osteoarthritis?

Clin Transl Med. 2024 Mar;14(3):e1634. doi: 10.1002/ctm2.1634.

Osteoarthritis year in review 2015: biology.

Osteoarthritis Cartilage. 2016 Jan;24(1):21-6. doi: 10.1016/j.joca.2015.09.010.

Aberrant subchondral osteoblastic metabolism modifies Na1.8 for osteoarthritis.

Elife. 2020 May 22;9:e57656. doi: 10.7554/eLife.57656.

Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat.

Neuroscience. 2015 Jun 4;295:103-16. doi: 10.1016/j.neuroscience.2015.03.042. Epub 2015 Mar 25.

Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes.

Histol Histopathol. 1999 Oct;14(4):1023-31. doi: 10.14670/HH-14.1023.

Downregulation of microRNA-448 inhibits IL-1β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3.

Cell Mol Biol Lett. 2018 Feb 22;23:7. doi: 10.1186/s11658-018-0072-6. eCollection 2018.

Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis.

Ann Rheum Dis. 2016 Jul;75(7):1372-9. doi: 10.1136/annrheumdis-2015-207487. Epub 2015 Aug 7.

PiRNA hsa_piR_019949 promotes chondrocyte anabolic metabolism by inhibiting the expression of lncRNA NEAT1.

J Orthop Surg Res. 2024 Jan 4;19(1):31. doi: 10.1186/s13018-023-04511-z.

Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction.

Biosci Rep. 2020 Jan 31;40(1). doi: 10.1042/BSR20191017.

Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis.

RMD Open. 2019 Sep 20;5(2):e001037. doi: 10.1136/rmdopen-2019-001037. eCollection 2019.

引用本文的文献

Sirtuin 2 regulates NOD-like receptor protein 3/nuclear factor kappa B axis to promote cartilage repair in osteoarthritis.

J Cell Commun Signal. 2025 Jul 3;19(3):e70031. doi: 10.1002/ccs3.70031. eCollection 2025 Sep.

Ion channels in osteoarthritis: emerging roles and potential targets.

Nat Rev Rheumatol. 2024 Sep;20(9):545-564. doi: 10.1038/s41584-024-01146-0. Epub 2024 Aug 9.

本文引用的文献

Na1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis.

Nature. 2024 Jan;625(7995):557-565. doi: 10.1038/s41586-023-06888-7. Epub 2024 Jan 3.

Targeting a Peripheral Sodium Channel to Treat Pain.

N Engl J Med. 2023 Aug 3;389(5):466-469. doi: 10.1056/NEJMe2305708.

14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis.

Ann Rheum Dis. 2021 Dec;80(12):1615-1627. doi: 10.1136/annrheumdis-2021-220000. Epub 2021 Jul 5.

TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity.

J Clin Invest. 2021 Aug 16;131(16). doi: 10.1172/JCI144016.

Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling.

Arthritis Rheumatol. 2016 Dec;68(12):2845-2856. doi: 10.1002/art.39816.

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling.

Ann Rheum Dis. 2015 Dec;74(12):2244-2253. doi: 10.1136/annrheumdis-2014-205779. Epub 2014 Aug 28.

Progranulin: a growth factor, a novel TNFR ligand and a drug target.

Pharmacol Ther. 2012 Jan;133(1):124-32. doi: 10.1016/j.pharmthera.2011.10.003. Epub 2011 Oct 8.

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10.

The role of ADAMTSs in arthritis.

Protein Cell. 2010 Jan;1(1):33-47. doi: 10.1007/s13238-010-0002-5. Epub 2010 Feb 7.

The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.

Nat Clin Pract Rheumatol. 2009 Jan;5(1):38-45. doi: 10.1038/ncprheum0961.