School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
Transl Vis Sci Technol. 2024 Mar 1;13(3):22. doi: 10.1167/tvst.13.3.22.
To determine if performing the isometric handgrip test (IHGT) can augment optical coherence tomography angiography (OCTA) vascular signal quality in eyes with macular abnormalities.
A randomized, single-blinded crossover trial was conducted including 36 participants with macular abnormalities, randomized to undergo OCTA with or without the IHGT, then crossed over to the alternate "intervention" after 1 minute. The primary outcome was OCTA signal quality after 1 minute of squeezing at 50% maximum grip strength. Secondary outcomes were other measures of vascular flow and systemic blood pressure (BP), also regressed against person- and eye-level covariables.
Primary analysis of OCTA signal quality with versus without the IHGT was nonsignificant (P = 0.73). Nested analyses showed that the IHGT resulted in increased OCTA B-scan retinal vascular flow signal (2.95 [-1.64 to 7.55] Δ%, P < 0.05) and increased systolic BP, diastolic BP, pulse pressure, and mean arterial pressure (4.94 [0.41 to 9.47] to 12.38 [8.01 to 16.75] mm Hg, P < 0.05). OCTA signal quality and en face vessel density and perfusion changes were associated with sex, refraction, race/ethnicity, and right-hand IHGT use (P < 0.05). Greater increases in systolic and diastolic BP and mean arterial pressure were generally associated with right-hand IHGT use and greater maximum grip strength (P < 0.09).
The IHGT can temporarily increase OCTA B-scan retinal vascular flow signal in participants with macular abnormalities. IHGT-induced changes to systemic BP appear to be linked to absolute (rather than relative) grip strength, implying that the IHGT may be ineffective with low grip strength. Further research in larger populations is warranted.
This study provides early validation that the IHGT may augment OCTA output, which may lead to improved noninvasive detection of pathologic vascular changes.
确定在黄斑病变的眼中进行等长握力测试（IHGT）是否可以增强光学相干断层扫描血管造影（OCTA）的血管信号质量。
进行了一项随机、单盲交叉试验，纳入 36 名黄斑病变患者，随机接受 OCTA 检查，或在接受 OCTA 检查前先进行 IHGT，1 分钟后交叉至另一种“干预”。主要结局是在以 50%最大握力进行 1 分钟挤压后 OCTA 信号质量。次要结局是其他血管流量和全身血压（BP）的测量值，也针对人与眼水平的协变量进行回归。
在有和没有 IHGT 的情况下，OCTA 信号质量的主要分析无统计学意义（P=0.73）。嵌套分析显示，IHGT 导致 OCTA B 扫描视网膜血管血流信号增加（2.95[-1.64 至 7.55]Δ%，P<0.05）和收缩压、舒张压、脉压和平均动脉压升高（4.94[0.41 至 9.47]至 12.38[8.01 至 16.75]mmHg，P<0.05）。OCTA 信号质量和额状血管密度和灌注变化与性别、屈光不正、种族/民族和右手 IHGT 使用有关（P<0.05）。收缩压、舒张压和平均动脉压的增加与右手 IHGT 使用和最大握力较高（P<0.09）一般相关。
IHGT 可暂时增加黄斑病变患者的 OCTA B 扫描视网膜血管血流信号。IHGT 引起的全身 BP 变化似乎与绝对（而非相对）握力有关，这表明 IHGT 在握力较低时可能无效。需要在更大的人群中进行进一步研究。
翻译后的文本符合中文表达习惯，语法正确，没有错别字。
