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冰山一角:通过一项全国性纵向队列研究揭示累积性体力工作暴露对背部疾病的影响并评估健康工人效应导致的偏差。

Tip of the iceberg: unveiling the impact on back disorders from cumulative physical job exposure and evaluating bias from the healthy worker effect using a nationwide longitudinal cohort study.

作者信息

Wiben Amalie, Skovsgaard Christian, Søgaard Karen, Schiøttz-Christensen Berit, Olsen Kim Rose

机构信息

Danish Centre for Health Economics, Department of Public Health, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

Research Unit of Physical Activity and Health in Working Life, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

出版信息

Eur Spine J. 2024 Jun;33(6):2395-2404. doi: 10.1007/s00586-024-08212-x. Epub 2024 Mar 26.

Abstract

PURPOSE

Longitudinal studies across various sectors with physically demanding jobs are notably absent in back disorder risk research. This study aimed to investigate the relationship between cumulative physical job exposure (PJE) and hospital-diagnosed back disorders among individuals in Denmark. To assess the healthy worker effect, we compared the cumulative risk estimate with results from a naive cross-sectional model ignoring PJE history.

METHODS

A nationwide longitudinal cohort study was conducted using Danish registers, encompassing individuals born between 1975 and 1978 and working in 1996. Cumulative PJE was measured with a 10-year look-back period for each year 2006-2017. PJE consisted of lower-body occupational exposures, including the total weight lifted, stand/sit ratio, and the frequency of lifting more than 20 kg per day from a job exposure matrix. Odds ratio for back disorders was estimated for each year and all years combined.

RESULTS

The results unveiled a significant 31% increase in the risk of hospital-diagnosed back disorders after 4 years of cumulative PJE. The lowest risk (7%) was observed for incident back disorders with 1 year of exposure, suggesting a healthy worker effect. Nevertheless, this risk is still significantly elevated. This cumulative estimate is fourfold the estimate from the 2006 naive cross section model.

CONCLUSION

Our study clearly demonstrates an 31% increase in the risk of hospital-diagnosed back disorders with just 4 years of PJE over a 10-year period. Further, we find that cross-sectional studies strongly underestimate the risk of back disorders due to the healthy worker effect.

摘要

目的

在背部疾病风险研究中,明显缺乏对从事体力要求较高工作的各个部门进行的纵向研究。本研究旨在调查丹麦个体中累积身体工作暴露(PJE)与医院诊断的背部疾病之间的关系。为了评估健康工人效应,我们将累积风险估计值与忽略PJE历史的简单横断面模型的结果进行了比较。

方法

利用丹麦登记册进行了一项全国性纵向队列研究,涵盖1975年至1978年出生且在1996年工作的个体。在2006 - 2017年的每一年中,以回顾10年的时间段来测量累积PJE。PJE包括下半身职业暴露,包括总举重重量、站立/坐姿比例以及从工作暴露矩阵中得出的每天举起超过20千克的频率。估计每年以及所有年份综合起来的背部疾病的优势比。

结果

结果显示,累积PJE 4年后,医院诊断的背部疾病风险显著增加31%。暴露1年的新发背部疾病风险最低(7%),表明存在健康工人效应。然而,这一风险仍然显著升高。这个累积估计值是2006年简单横断面模型估计值的四倍。

结论

我们的研究清楚地表明,在10年期间仅4年的PJE就使医院诊断的背部疾病风险增加了31%。此外,我们发现横断面研究由于健康工人效应而严重低估了背部疾病的风险。

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