前列环素的代谢产物6-酮-前列腺素E1的降压及肾血管作用。
Hypotensive and renovascular actions of 6-keto-prostaglandin E1, a metabolite of prostacyclin.
作者信息
Quilley C P, Wong P Y, McGiff J C
出版信息
Eur J Pharmacol. 1979 Aug 1;57(2-3):273-6. doi: 10.1016/0014-2999(79)90378-9.
PMID:385331
Abstract
Either intra-aortic or intravenous injections of a stable prostaglandin metabolite, 6-keto-prostaglandin E1 (6-keto-PGE1), caused similar dose-dependent falls in blood pressure and reductions in renovascular resistance in the anesthetized rat. The threshold dose was 0.3 microgram/kg. A maximum hypotensive effect occured at 10 micrograms/kg, but renal blood flow was further reduced by a dose of 30 microgram/kg. 6-keto-PGE1, like prostacyclin, could be a circulating hormone.
摘要
在麻醉大鼠中，主动脉内或静脉注射稳定的前列腺素代谢产物6-酮-前列腺素E1（6-keto-PGE1），均可引起类似的剂量依赖性血压下降和肾血管阻力降低。阈剂量为0.3微克/千克。10微克/千克时出现最大降压效果，但30微克/千克剂量会使肾血流量进一步降低。6-keto-PGE1与前列环素一样，可能是一种循环激素。
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