前列环素、6-氧代前列腺素F1α与前列腺素E2对大鼠和家兔血管降压作用的比较。
Comparison of the vasodepressor effects of prostacyclin and 6-oxo-prostaglandin F1alpha with those of prostaglandin E2 in rats and rabbits.
作者信息
Armstrong J M, Lattimer N, Moncada S, Vane J R
出版信息
Br J Pharmacol. 1978 Jan;62(1):125-30. doi: 10.1111/j.1476-5381.1978.tb07014.x.
Abstract
1 Vasodepressor effects of prostacyclin (5z-5,6-didehydro-9-deoxy-6,9alpha-epoxyprostaglandin F1) and its decomposition product 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha) have been compared with those of prostaglandin E2 (PGE2) in anaesthetized rats and rabbits. 2 In rats intravenous prostacyclin produced hypotension and was 4--8 times more potent than PGE2 and about 128 times more potent than 6-oxo-PGF1alpha. 3 In rabbits also, intravenous prostacyclin (less than 2 microgram/kg) produced hypotension and was twice as active as PGE2 and approximately 250 times more active than 6-oxo-PGF1alpha. 4 In rats and rabbits vasodepressor responses induced by prostacyclin were similar in magnitude after either intravenous or intra-aortic administration. 5 Thus, in both species prostacyclin resembles PGE2 in producing vasodepression but does not lose activity on passage through the lungs. The results emphasize the need to consider prostacyclin in addition to PGE2 as a major determinant influencing blood pressure.
摘要
1 已在麻醉大鼠和兔中比较了前列环素（5Z-5,6-二脱氢-9-脱氧-6,9α-环氧前列腺素F1）及其分解产物6-氧代前列腺素F1α（6-氧代-PGF1α）与前列腺素E2（PGE2）的血管降压作用。2 在大鼠中，静脉注射前列环素可产生低血压，其效力比PGE2强4至8倍，比6-氧代-PGF1α强约128倍。3 在兔中，静脉注射前列环素（小于2微克/千克）也可产生低血压，其活性是PGE2的两倍，比6-氧代-PGF1α高约250倍。4 在大鼠和兔中，静脉注射或主动脉内注射前列环素所诱导的血管降压反应幅度相似。5 因此，在这两个物种中，前列环素在产生血管降压作用方面类似于PGE2，但在通过肺时不会丧失活性。结果强调除了PGE2之外，还需要将前列环素视为影响血压的主要决定因素。
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Prostaglandins: their disappearance from and release into the circulation.前列腺素：它们在循环系统中的消失与释放
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The antihypertensive action of arachidonic acid in the spontaneous hypertensive rat and its antagonism by anti-inflammatory agents.花生四烯酸在自发性高血压大鼠中的降压作用及其被抗炎药的拮抗作用。
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