Department of Polymer and Biomaterials Science, West Pomeranian University of Technology, Szczecin, Poland.
Polim Med. 2024 Jan-Jun;54(1):59-69. doi: 10.17219/pim/184535.
Today's growing demand for advanced and sustainable polyester materials is driven by an increasing awareness of the environmental impact of traditional materials, emphasizing the need for eco-friendly alternatives. Sustainability has become central in materials development, including the biomedical area, where biobased and environmentally friendly solutions are a rapidly growing field.
This research aims to comprehensively evaluate a new enzymatically catalyzed furan-based copolymer, poly(decamethylene furanoate)-co-(dilinoleic furanoate) (PDF-DLF), with a 70-30 wt% hard-to-soft segment ratio. Then, its performance across medical applications is explored, with a particular focus on its potential as a nanofibrous scaffolding material.
PDF-DLF was synthesized from biobased monomers using Candida antarctica lipase B (CAL-B) as the biocatalyst. Material characterization included dynamic mechan‑ical thermal analysis (DMTA) to assess the mechanical behavior and thermal properties. Enzymatic degradation studies determined biodegradability, while cytotoxicity tests established in vitro biocompatibility. The copolymer was electrospun into nanofibers, with scanning electron microscopy (SEM) employed to analyze their morphology.
PDF-DLF displays mechanical and thermal properties indicating high storage modulus and 2 main temperature transitions. Enzymatic degradation studies and cytotoxicity assessments confirm biodegradability and in vitro biocompatibility. Electrospinning successfully transformed the copolymer into nanofibers with diameters ranging from 500 nm to 700 nm.
This study significantly advances our understanding of sustainable polyesters with versatile processing capabilities. The successful electrospinning highlights its potential as a biodegradable scaffold for medical engineering, supported by biocompatibility and sufficient mechanical properties. It opens new opportunities for sustainable materials in critical biomedical industries, including tissue engineering.
当今对先进和可持续聚酯材料的需求不断增长，这是由于人们越来越意识到传统材料对环境的影响，强调需要环保替代品。可持续性已成为材料开发的核心，包括生物医学领域，生物基和环保解决方案是一个快速发展的领域。
本研究旨在全面评估一种新型酶催化呋喃基共聚酯，聚（十亚甲基呋喃酸）-共-（亚油酸呋喃酸）（PDF-DLF），其硬段-软段比为 70-30wt%。然后，探索其在医学应用中的性能，特别关注其作为纳米纤维支架材料的潜力。
PDF-DLF 是由生物基单体通过南极假丝酵母脂肪酶 B（CAL-B）作为生物催化剂合成的。材料特性包括动态力学热分析（DMTA），以评估其机械性能和热性能。酶促降解研究确定了生物降解性，而体外细胞毒性测试则确定了生物相容性。共聚物被电纺成纳米纤维，使用扫描电子显微镜（SEM）分析其形态。
PDF-DLF 显示出机械和热性能，表明具有较高的储能模量和 2 个主要的温度转变。酶促降解研究和细胞毒性评估证实了生物降解性和体外生物相容性。成功地将共聚物电纺成直径在 500nm 到 700nm 之间的纳米纤维。
本研究显著提高了我们对具有多功能加工能力的可持续聚酯的理解。成功的电纺突出了其作为生物降解支架在医学工程中的潜力，支持其生物相容性和足够的机械性能。它为包括组织工程在内的关键生物医学产业中的可持续材料开辟了新的机会。
