Laboratory for Biomaterial and ImmunoEngineering, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Nanoscale. 2024 Apr 25;16(16):7825-7840. doi: 10.1039/d3nr05470e.
Extracellular vesicles (EVs) are natural particles secreted by living cells, which hold significant potential for various therapeutic applications. Native EVs have specific components and structures, allowing them to cross biological barriers, and circulate for a long time. Native EVs have also been bioengineered to enhance their therapeutic efficacy and targeting affinity. Recently, the therapeutic potential of surface-engineered EVs has been explored in the treatment of tumors, autoimmune diseases, infections and other diseases by ongoing research and clinical trials. In this review, we will introduce the modified methods of engineered EVs, summarize the application of engineered EVs in preclinical and clinical trials, and discuss the opportunities and challenges for the clinical translation of surface-engineered EVs.
细胞外囊泡（EVs）是活细胞分泌的天然颗粒，具有广泛的治疗应用潜力。天然 EVs 具有特定的组成和结构，使其能够穿越生物屏障，并长时间循环。天然 EVs 也经过生物工程改造以增强其治疗效果和靶向亲和力。最近，通过正在进行的研究和临床试验，表面工程化 EVs 的治疗潜力已在肿瘤、自身免疫性疾病、感染和其他疾病的治疗中得到了探索。在这篇综述中，我们将介绍工程化 EVs 的修饰方法，总结工程化 EVs 在临床前和临床试验中的应用，并讨论表面工程化 EVs 临床转化的机遇和挑战。
