Mehraj Insha, Hamid Aflaq, Gani Ubaid, Iralu Nulevino, Manzoor Tasaduq, Saleem Bhat Sahar
Division of Animal Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, Jammu and Kashmir 05466, India.
Department of Plant Pathology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, Jammu and Kashmir 05466, India.
ACS Appl Bio Mater. 2024 Apr 15;7(4):2023-2035. doi: 10.1021/acsabm.3c01104. Epub 2024 Mar 27.
The rising prevalence of multiple-drug-resistant pathogens poses a formidable challenge to conventional antimicrobial treatments. The inability of potent antibiotics to combat these "superbugs" underscores the pressing need for alternative therapeutic agents. Antimicrobial peptides (AMPs) represent an alternative class of antibiotics. AMPs are essential immunomodulatory molecules that are found in various organisms. They play a pivotal role in managing microbial ecosystems and bolstering innate immunity by targeting and eliminating invading microorganisms. AMPs also have applications in the agriculture sector by combating animal as well as plant pathogens. AMPs can be exploited for the targeted therapy of various diseases and can also be used in drug-delivery systems. They can be used in synergy with current treatments like antibiotics and can potentially lead to a lower required dosage. AMPs also have huge potential in wound healing and regenerative medicine. Developing AMP-based strategies with improved safety, specificity, and efficacy is crucial in the battle against alarming global microbial resistance. This review will explore AMPs' increasing applicability, their mode of antimicrobial activity, and various delivery systems enhancing their stability and efficacy.
多重耐药病原体的日益流行对传统抗菌治疗构成了巨大挑战。强效抗生素无法对抗这些“超级细菌”凸显了对替代治疗剂的迫切需求。抗菌肽（AMPs）是一类替代抗生素。AMPs是在各种生物体中发现的重要免疫调节分子。它们通过靶向和消除入侵微生物在管理微生物生态系统和增强先天免疫方面发挥关键作用。AMPs在农业领域也有应用，可对抗动物和植物病原体。AMPs可用于各种疾病的靶向治疗，也可用于药物递送系统。它们可与抗生素等现有治疗方法协同使用，并可能降低所需剂量。AMPs在伤口愈合和再生医学方面也有巨大潜力。制定具有更高安全性、特异性和疗效的基于AMPs的策略对于应对全球令人担忧的微生物耐药性至关重要。本综述将探讨AMPs日益增加的适用性、它们的抗菌活性模式以及增强其稳定性和疗效的各种递送系统。
