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Reduced critical concentration might not have improved MGIT-based DST's sensitivity to rifampicin.临界浓度降低可能并未提高基于分枝杆菌生长指示管的药物敏感性试验对利福平的敏感性。
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2
Reevaluating Rifampicin Breakpoint Concentrations for Mycobacterium tuberculosis Isolates with Disputed Mutations and Discordant Susceptibility Phenotypes.重新评估具有争议性突变和不一致药敏表型的结核分枝杆菌分离株的利福平断点浓度。
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Discordant results between Xpert MTB/RIF assay and Bactec MGIT 960 culture system regarding the detection of rifampin-resistant isolates in Wenzhou, China.Xpert MTB/RIF assay 与 Bactec MGIT 960 培养系统在检测中国温州耐利福平分离株方面的结果不一致。
Microbiol Spectr. 2024 Jun 4;12(6):e0385923. doi: 10.1128/spectrum.03859-23. Epub 2024 May 13.
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True rifampicin resistance missed by the MGIT: prevalence of this pheno/genotype in the UK and Ireland after 18 month surveillance.英国和爱尔兰 18 个月监测后 MGIT 漏检的真实利福平耐药：该表型/基因型的流行率。
Clin Microbiol Infect. 2017 Apr;23(4):260-263. doi: 10.1016/j.cmi.2016.11.015. Epub 2016 Nov 27.
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Performance Evaluation of the BACTEC MGIT 960 System for Rifampin Drug-Susceptibility Testing of Mycobacterium tuberculosis Using the Current WHO Critical Concentration.BACTEC MGIT 960 系统对利福平药物敏感性测试在当前世卫组织临界浓度下结核分枝杆菌的性能评估。
J Clin Microbiol. 2023 Jan 26;61(1):e0108622. doi: 10.1128/jcm.01086-22. Epub 2023 Jan 5.
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Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of multidrug-resistant tuberculosis.在一个耐药结核病发病率较低的国家，表型上对利福平敏感的结核分枝杆菌分离株中出现有争议的 rpoB 突变。
BMC Infect Dis. 2019 Jan 3;19(1):3. doi: 10.1186/s12879-018-3638-z.
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Rifampin resistance missed in automated liquid culture system for Mycobacterium tuberculosis isolates with specific rpoB mutations.利福平耐药性在特定 rpoB 突变的结核分枝杆菌分离株自动化液体培养系统中漏检。
J Clin Microbiol. 2013 Aug;51(8):2641-5. doi: 10.1128/JCM.02741-12. Epub 2013 Jun 12.
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Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin.基因型和表型药敏结果的不一致：是时候重新考虑利福平的临界浓度了。
Microbiol Spectr. 2025 Mar 4;13(3):e0223624. doi: 10.1128/spectrum.02236-24. Epub 2025 Feb 4.
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Evaluation of the fully automated Bactec MGIT 960 system for the susceptibility testing of Mycobacterium tuberculosis to first-line drugs: a multicenter study.全自动Bactec MGIT 960系统用于结核分枝杆菌对一线药物药敏试验的评估：一项多中心研究。
J Microbiol Methods. 2004 Feb;56(2):291-4. doi: 10.1016/j.mimet.2003.10.015.
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Mycobacterial growth indicator tube for susceptibility testing of Mycobacterium tuberculosis to isoniazid and rifampin.用于结核分枝杆菌对异烟肼和利福平药敏试验的分枝杆菌生长指示管
Diagn Microbiol Infect Dis. 1997 Jul;28(3):153-6. doi: 10.1016/s0732-8893(97)00006-0.

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1
Series 2: Development of a Multiplex Amplicon Next Generation Sequencing Assay for Rapid Assessment of Resistance-Associated Mutations in Clinical Cases.系列2：开发用于快速评估临床病例中耐药相关突变的多重扩增子新一代测序检测方法。
Trop Med Infect Dis. 2025 Jul 10;10(7):194. doi: 10.3390/tropicalmed10070194.

本文引用的文献

1
Borderline mutations transmit at the same rate as common mutations in a tuberculosis cohort in Bangladesh.孟加拉国结核队列中，交界突变的传播率与常见突变相同。
Microb Genom. 2023 Sep;9(9). doi: 10.1099/mgen.0.001109.
2
Discordant results between genotypic and phenotypic assays (Xpert MTB/RIF vs. BACTEC MGIT 960 system) for detection of RIF-resistant Mycobacterium tuberculosis isolates in a high burden region.在高负担地区检测耐利福平结核分枝杆菌分离株时，基因分型检测与表型检测（Xpert MTB/RIF与BACTEC MGIT 960系统）结果不一致。
Infect Genet Evol. 2021 Dec;96:105142. doi: 10.1016/j.meegid.2021.105142. Epub 2021 Nov 17.
3
Mechanisms and detection methods of Mycobacterium tuberculosis rifampicin resistance: The phenomenon of drug resistance is complex.结核分枝杆菌利福平耐药的机制和检测方法：耐药现象复杂。
Tuberculosis (Edinb). 2021 May;128:102083. doi: 10.1016/j.tube.2021.102083. Epub 2021 May 8.
4
borderline mutations: emerging from the unknown.临界突变：从未知中浮现
Eur Respir J. 2021 Sep 2;58(3). doi: 10.1183/13993003.00783-2021. Print 2021 Sep.
5
Correlation between genotypic and phenotypic testing for resistance to rifampin in Mycobacterium tuberculosis clinical isolates in Haiti: investigation of cases with discrepant susceptibility results.海地结核分枝杆菌临床分离株中利福平耐药性的基因型与表型检测之间的相关性：药敏结果不一致病例的调查
PLoS One. 2014 Mar 5;9(3):e90569. doi: 10.1371/journal.pone.0090569. eCollection 2014.
6
Rifampin drug resistance tests for tuberculosis: challenging the gold standard.利福平耐药结核病检测：挑战金标准。
J Clin Microbiol. 2013 Aug;51(8):2633-40. doi: 10.1128/JCM.00553-13. Epub 2013 Jun 12.

Reduced critical concentration might not have improved MGIT-based DST's sensitivity to rifampicin.

作者信息

Rupasinghe Praharshinie, Ashraf Azka, Barreda Nadia, Parveen Shafiqua, Zubair Muhammad, Calderon Roger, Asif Sunil, Hirani Nilma, Chingisova Layila, Bulane Atang, Hang Pham Thu, Ha Doan Thu, Ardizzoni Elisa, Kursheed Nazia, De Rijk Willem Bram, Rigouts Leen, Guglielmetti Lorenzo, Mitnick Carol, de Jong Bouke C

机构信息

Unit of Mycobacteriology, Institute of Tropical Medicine, Antwerp, Belgium.

Department of Biomedical Sciences, University of Antwerp, Wilrijk, Antwerp, Belgium.

出版信息

Antimicrob Agents Chemother. 2024 May 2;68(5):e0170123. doi: 10.1128/aac.01701-23. Epub 2024 Mar 27.

DOI:10.1128/aac.01701-23
PMID:38534101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11064607/
Abstract
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