Zhang Peilin, Hu Jiacheng, Liu Xiaonan, Li Yanhao, Pang Sa, Liu Shen
Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration, Shanghai, China.
Tissue Eng Part B Rev. 2025 Feb;31(1):20-30. doi: 10.1089/ten.TEB.2023.0313. Epub 2024 Apr 12.
The healing process after tendon injury is often accompanied by the formation of peritendinous adhesion, contributing to limb dysfunction and exerting detrimental effects on the individuals, as well as the development of society and economy. With the continuous development of material science, as well as the augmented understanding of tendon healing and the mechanism of peritendinous adhesion formation, materials used for the fabrication of barrier membranes against peritendinous adhesion emerge endlessly. In this article, based on the analysis of the mechanism of adhesion formation, we first review the commonly used natural and synthetic materials, along with their corresponding fabrication strategies, in order to furnish valuable insights for the future optimization and development of antiperitendinous adhesion barrier membranes. This article also discusses the interaction between antiadhesion materials and cells for ameliorating peritendinous adhesion.
肌腱损伤后的愈合过程常伴有腱周粘连的形成，这会导致肢体功能障碍，对个人以及社会和经济发展产生不利影响。随着材料科学的不断发展，以及对肌腱愈合和腱周粘连形成机制的深入了解，用于制造防止腱周粘连的屏障膜的材料层出不穷。在本文中，基于对粘连形成机制的分析，我们首先回顾常用的天然和合成材料及其相应的制备策略，以便为未来抗腱周粘连屏障膜的优化和发展提供有价值的见解。本文还讨论了抗粘连材料与细胞之间的相互作用，以改善腱周粘连。
