手术在转移性黑色素瘤中的作用及黑色素瘤分子特征综述。
Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics.
机构信息
Department of General Surgery, Duke University Medical Center, Durham, NC 27707, USA.
Department of Medicine, Government Medical College and Hospital, Chandigarh 160047, India.
出版信息
Cells. 2024 Mar 7;13(6):465. doi: 10.3390/cells13060465.
Abstract
We aimed to review the molecular characteristics of metastatic melanoma and the role of surgery in metastasectomy for metastatic melanoma. We performed a systematic literature search on PubMed to identify relevant studies focusing on several mutations, including NRAS, BRAF, NF1, MITF, PTEN, TP53, CDKN2A, TERT, TMB, EGFR, and c-KIT. This was performed in the context of metastatic melanoma and the role of metastasectomy in the metastatic melanoma population. A comprehensive review of these molecular characteristics is presented with a focus on their prognosis and role in surgical metastasectomy.
摘要
我们旨在回顾转移性黑色素瘤的分子特征以及手术在转移性黑色素瘤转移灶切除术（metastasectomy）中的作用。我们在 PubMed 上进行了系统的文献检索，以确定几项突变的相关研究，包括 NRAS、BRAF、NF1、MITF、PTEN、TP53、CDKN2A、TERT、TMB、EGFR 和 c-KIT。这是在转移性黑色素瘤的背景下进行的，以及在转移性黑色素瘤患者中转移灶切除术的作用。我们全面回顾了这些分子特征，重点介绍了它们的预后和在手术转移灶切除中的作用。
相似文献
1
Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics.手术在转移性黑色素瘤中的作用及黑色素瘤分子特征综述。
Cells. 2024 Mar 7;13(6):465. doi: 10.3390/cells13060465.
2
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
3
Immunohistochemistry as a reliable method for detection of BRAF-V600E mutation in melanoma: a systematic review and meta-analysis of current published literature.免疫组织化学作为检测黑色素瘤中BRAF-V600E突变的可靠方法：对当前已发表文献的系统评价和荟萃分析
J Surg Res. 2016 Jun 15;203(2):407-15. doi: 10.1016/j.jss.2016.04.029. Epub 2016 Apr 23.
4
Genetic Concordance in Primary Cutaneous Melanoma and Matched Metastasis: A Systematic Review and Meta-Analysis.原发皮肤黑色素瘤及其配对转移灶的遗传一致性：系统评价和荟萃分析。
Int J Mol Sci. 2023 Nov 14;24(22):16281. doi: 10.3390/ijms242216281.
5
Sentinel lymph node biopsy followed by lymph node dissection for localised primary cutaneous melanoma.前哨淋巴结活检后行局部原发性皮肤黑色素瘤淋巴结清扫术。
Cochrane Database Syst Rev. 2015 May 16;2015(5):CD010307. doi: 10.1002/14651858.CD010307.pub2.
6
Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma.BRAF 突变与原发性黑色素瘤临床病理特征的荟萃分析
J Am Acad Dermatol. 2015 Jun;72(6):1036-46.e2. doi: 10.1016/j.jaad.2015.02.1113. Epub 2015 Mar 25.
7
Mitogen-activated protein kinase (MEK) inhibitors to treat melanoma alone or in combination with other kinase inhibitors.丝裂原活化蛋白激酶（MEK）抑制剂，用于单独治疗黑色素瘤或与其他激酶抑制剂联合使用。
Expert Opin Drug Metab Toxicol. 2018 Mar;14(3):317-330. doi: 10.1080/17425255.2018.1432593. Epub 2018 Jan 30.
8
Survival of patients with metastatic melanoma and brain metastases in the era of MAP-kinase inhibitors and immunologic checkpoint blockade antibodies: A systematic review.接受 MAP-kinase 抑制剂和免疫检查点阻断抗体治疗的转移性黑色素瘤和脑转移患者的生存：系统评价。
Cancer Treat Rev. 2016 Apr;45:38-45. doi: 10.1016/j.ctrv.2016.03.003. Epub 2016 Mar 8.
9
Neoadjuvant treatment for stage III and IV cutaneous melanoma.新辅助治疗 III 期和 IV 期皮肤黑色素瘤。
Cochrane Database Syst Rev. 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2.
10
A comprehensive, multi-center, immunogenomic analysis of melanoma brain metastases.黑色素瘤脑转移的全面、多中心免疫基因组分析。
Acta Neuropathol Commun. 2025 Jun 2;13(1):123. doi: 10.1186/s40478-025-02035-7.
引用本文的文献
1
Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report.一例患有三种不同恶性肿瘤——皮肤恶性黑色素瘤、胃肠道间质瘤和甲状腺乳头状癌的患者长期存活：病例报告
Oncol Lett. 2025 Jul 14;30(3):439. doi: 10.3892/ol.2025.15185. eCollection 2025 Sep.
2
CDKN2A, a key gene in copper-induced cell death model, influencing melanoma invasion and apoptosis.CDKN2A是铜诱导细胞死亡模型中的关键基因，影响黑色素瘤的侵袭和凋亡。
Discov Oncol. 2025 Feb 27;16(1):246. doi: 10.1007/s12672-025-01992-8.
3
Liquid Crystalline Networks Hamper the Malignancy of Cancer Cells.液晶网络抑制癌细胞的恶性增殖。
Adv Healthc Mater. 2025 Mar;14(7):e2403607. doi: 10.1002/adhm.202403607. Epub 2025 Jan 19.
4
Expression of c-erb-B2 oncoprotein as a neoantigen strategy to repurpose anti-neu antibody therapy in a model of melanoma.c-erb-B2 癌蛋白表达作为一种新抗原策略，用于重新利用抗神经抗体治疗黑色素瘤模型。
Sci Rep. 2024 Oct 19;14(1):24545. doi: 10.1038/s41598-024-76209-z.
5
Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy.紫外线（UV）辐射：在癌症发展和治疗中的双刃剑。
Mol Biomed. 2024 Oct 17;5(1):49. doi: 10.1186/s43556-024-00209-8.
6
Feasibility and Impact of Embedding an Extended DNA and RNA Tissue-Based Sequencing Panel for the Routine Care of Patients with Advanced Melanoma in Spain.在西班牙，将一个扩展的 DNA 和 RNA 组织测序面板纳入晚期黑色素瘤患者常规护理的可行性和影响。
Int J Mol Sci. 2024 Jun 25;25(13):6942. doi: 10.3390/ijms25136942.
本文引用的文献
1
Significant and Various Effects of ML329-Induced MITF Suppression in the Melanoma Cell Line.ML329诱导的MITF抑制在黑色素瘤细胞系中的显著且多样的作用
Cancers (Basel). 2024 Jan 7;16(2):263. doi: 10.3390/cancers16020263.
2
Gene Mutations: Implications for Hereditary Cancer Syndromes.基因突变：对遗传性癌症综合征的影响
Biomedicines. 2023 Dec 18;11(12):3343. doi: 10.3390/biomedicines11123343.
3
Phosphatase and Tensin Homolog (PTEN) Expression as a Surrogate Biomarker Correlated With the Depth of Invasion in Cutaneous Malignant Melanoma.磷酸酶与张力蛋白同源物（PTEN）表达作为与皮肤恶性黑色素瘤浸润深度相关的替代生物标志物
Cureus. 2023 Sep 15;15(9):e45295. doi: 10.7759/cureus.45295. eCollection 2023 Sep.
4
TP53 and its Regulatory Genes as Prognosis of Cutaneous Melanoma.TP53 及其调控基因作为皮肤黑色素瘤的预后指标
Cancer Inform. 2023 Aug 31;22:11769351231177267. doi: 10.1177/11769351231177267. eCollection 2023.
5
Primary tumour category, site of metastasis, and baseline serum S100B and LDH are independent prognostic factors for survival in metastatic melanoma patients treated with anti-PD-1.原发性肿瘤类别、转移部位以及基线血清S100B和乳酸脱氢酶（LDH）是接受抗程序性死亡蛋白1（PD-1）治疗的转移性黑色素瘤患者生存的独立预后因素。
Front Oncol. 2023 Aug 17;13:1237643. doi: 10.3389/fonc.2023.1237643. eCollection 2023.
6
Metastasectomy in Stage IV Melanoma: How and When Should We Employ It?IV期黑色素瘤的转移灶切除术：我们应如何以及何时应用它？
Ann Surg Oncol. 2023 Sep;30(9):5312-5313. doi: 10.1245/s10434-023-13760-5. Epub 2023 Jun 16.
7
Metastasectomy for metastatic melanoma in the era of effective systemic therapy.转移性黑色素瘤转移灶切除术在有效全身治疗时代。
Am J Surg. 2024 May;231:65-69. doi: 10.1016/j.amjsurg.2023.04.020. Epub 2023 May 23.
8
TERT Expression Induces Resistance to BRAF and MEK Inhibitors in BRAF-Mutated Melanoma In Vitro.端粒酶逆转录酶（TERT）表达在体外诱导BRAF突变型黑色素瘤对BRAF和MEK抑制剂产生耐药性。
Cancers (Basel). 2023 May 24;15(11):2888. doi: 10.3390/cancers15112888.
9
Surgical Resection of Pulmonary Metastases from Melanoma in Oligometastatic Patients: Results from a Multicentric Study in the Era of Immunoncology and Targeted Therapy.寡转移患者黑色素瘤肺转移的手术切除：免疫肿瘤学和靶向治疗时代的多中心研究结果
Cancers (Basel). 2023 Apr 25;15(9):2462. doi: 10.3390/cancers15092462.
10
Surveillance, CDKN2A and survival of familial melanoma.家族性黑色素瘤的监测、CDKN2A与生存情况
J Eur Acad Dermatol Venereol. 2023 Feb;37(2):218-219. doi: 10.1111/jdv.18796.
Zotero 插件