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超越传统医学：载有细胞外囊泡的水凝胶成为疾病治疗的变革者。

Beyond Traditional Medicine: EVs-Loaded Hydrogels as a Game Changer in Disease Therapeutics.

作者信息

Du Shutong, Zhou Xiaohu, Zheng Bo

机构信息

Institute for Cell Analysis, Shenzhen Bay Laboratory, Shenzhen 518132, China.

出版信息

Gels. 2024 Feb 21;10(3):162. doi: 10.3390/gels10030162.

DOI:10.3390/gels10030162
PMID:38534580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10970166/
Abstract

Extracellular vesicles (EVs), especially exosomes, have shown great therapeutic potential in the treatment of diseases, as they can target cells or tissues. However, the therapeutic effect of EVs is limited due to the susceptibility of EVs to immune system clearance during transport in vivo. Hydrogels have become an ideal delivery platform for EVs due to their good biocompatibility and porous structure. This article reviews the preparation and application of EVs-loaded hydrogels as a cell-free therapy strategy in the treatment of diseases. The article also discusses the challenges and future outlook of EVs-loaded hydrogels.

摘要

细胞外囊泡（EVs），尤其是外泌体，在疾病治疗中已显示出巨大的治疗潜力，因为它们可以靶向细胞或组织。然而，由于EVs在体内运输过程中易受免疫系统清除的影响，其治疗效果受到限制。水凝胶因其良好的生物相容性和多孔结构，已成为EVs的理想递送平台。本文综述了载有EVs的水凝胶作为一种无细胞治疗策略在疾病治疗中的制备和应用。本文还讨论了载有EVs的水凝胶面临的挑战和未来展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/fb6844080cc3/gels-10-00162-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/0836f51d9bc5/gels-10-00162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/d37e43c3609c/gels-10-00162-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/e48dd0886695/gels-10-00162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/dc612c633089/gels-10-00162-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/d18af108e6f5/gels-10-00162-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/ca34a0cb0442/gels-10-00162-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/fb6844080cc3/gels-10-00162-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/0836f51d9bc5/gels-10-00162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/d37e43c3609c/gels-10-00162-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/e48dd0886695/gels-10-00162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/dc612c633089/gels-10-00162-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/d18af108e6f5/gels-10-00162-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/ca34a0cb0442/gels-10-00162-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f34e/10970166/fb6844080cc3/gels-10-00162-g007.jpg

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