Zhang Jian, Jiang Shasha, Jiang Jipeng, Liu Yang
School of Medicine, Nankai University, Tianjin, China.
Department of Thoracic Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Front Digit Health. 2025 Mar 4;7:1472753. doi: 10.3389/fdgth.2025.1472753. eCollection 2025.
Acute lung injury is a common respiratory emergency that seriously affects the life, health and quality of life of patients, especially after the global COVID-19 pneumonia. The application of nanotechnology in acute lung injury is promising. In response to the knowledge explosion resulting from rapid publication growth, we applied bibliometric analysis to explore the research profile and thematic trends in the field.
Articles and reviews related to nanotechnology in acute lung injury from 2004 to 2023 were searched. Java-based Citespace, VOSviewer, and R software-based Bibiometrix were used to systematically evaluate publications by spatiotemporal distribution, author distribution, subject categories, topic distribution, references, and keywords.
A total of 1,347 publications were included. The number of papers related to nanotechnology in acute lung injury has grown exponentially over the past 20 years. China was the most productive country out of all 53 countries, followed by the United States. The Chinese Academy of Sciences was the most productive institution with 76 papers. was the most productive journal. The top five high-frequency keywords were inflammation, oxidative stress, toxicity, , respiratory-distress-syndrome. And the top five emerging keywords were delivery, covid-19, extracellular vesicles, therapy, sars-cov-2. Drug delivery are the focus of current research. Two emerging research areas represented the development trends: novel nanocarriers with higher efficiency and lower biotoxicity, and the other is research related to impact of nanomaterials in the progression of acute lung injury.
The field of nanotechnology in acute lung injury has been in a period of rapid development in the last three years. Delivery,targeted delivery and exosm have been the focus of current research in this field. Two emerging research areas represented the development trends:novel nanocarriers with higher efficiency and lower biotoxicity such as extracellular vesicles, exosomes and solid lipid nanoparticles, and the other is research related to impact of nanomaterials in the progression of acute lung injury.
急性肺损伤是一种常见的呼吸急症，严重影响患者的生命、健康和生活质量，尤其是在全球新型冠状病毒肺炎疫情之后。纳米技术在急性肺损伤中的应用前景广阔。为应对快速增长的出版物导致的知识爆炸，我们应用文献计量学分析来探索该领域的研究概况和主题趋势。
检索了2004年至2023年与纳米技术在急性肺损伤中的应用相关的文章和综述。使用基于Java的Citespace、VOSviewer以及基于R软件的Bibiometrix，通过时空分布、作者分布、学科类别、主题分布、参考文献和关键词对出版物进行系统评估。
共纳入1347篇出版物。在过去20年中，与纳米技术在急性肺损伤中的应用相关的论文数量呈指数增长。在所有53个国家中，中国是发文量最多的国家，其次是美国。中国科学院是发文量最多的机构，有76篇论文。 是发文量最多的期刊。高频关键词前五位是炎症、氧化应激、毒性、 、呼吸窘迫综合征。新兴关键词前五位是递送、新冠病毒-19、细胞外囊泡、治疗、严重急性呼吸综合征冠状病毒2。药物递送是当前研究的重点。两个新兴研究领域代表了发展趋势：具有更高效率和更低生物毒性的新型纳米载体，另一个是与纳米材料在急性肺损伤进展中的影响相关的研究。
纳米技术在急性肺损伤领域在过去三年一直处于快速发展时期。递送、靶向递送和外渗一直是该领域当前研究的重点。两个新兴研究领域代表了发展趋势：具有更高效率和更低生物毒性的新型纳米载体，如细胞外囊泡、外泌体和固体脂质纳米粒，另一个是与纳米材料在急性肺损伤进展中的影响相关的研究。
