Sid Ahmed Mazen A, Hamid Jemal M, Hassan Ahmed M M, Abu Jarir Sulieman, Bashir Ibrahim Emad, Abdel Hadi Hamad
Laboratory Services, Department of Public Health, Philadelphia, PA 19146, USA.
Division of Microbiology, Department of Pathology and Laboratory Medicine, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar.
Antibiotics (Basel). 2024 Mar 19;13(3):275. doi: 10.3390/antibiotics13030275.
In secondary healthcare, carbapenem-resistant Enterobacterales (CREs), such as those observed in , are a global public health priority with significant clinical outcomes. In this study, we described the clinical, phenotypic, and genotypic characteristics of three pan-drug-resistant (PDR) isolates that demonstrated extended resistance to conventional and novel antimicrobials. All patients had risk factors for the acquisition of multidrug-resistant organisms, while microbiological susceptibility testing showed resistance to all conventional antimicrobials. Advanced susceptibility testing demonstrated resistance to broad agents, such as ceftazidime-avibactam, ceftolozane-tazobactam, and meropenem-vaborbactam. Nevertheless, all isolates were susceptible to cefiderocol, suggested as one of the novel antimicrobials that demonstrated potent in vitro activity against resistant Gram-negative bacteria, including CREs, pointing toward its potential therapeutic role for PDR pathogens. Expanded genomic studies revealed multiple antimicrobial-resistant genes (ARGs), including and derivative types, as well as a mutated outer membrane porin protein (OmpK37).
在二级医疗保健中，耐碳青霉烯类肠杆菌科细菌（CREs），例如在[具体情况未提及处]观察到的那些，是具有重大临床后果的全球公共卫生重点关注对象。在本研究中，我们描述了三株全耐药（PDR）分离株的临床、表型和基因型特征，这些分离株对传统和新型抗菌药物均表现出广泛耐药性。所有患者均有获得多重耐药菌的危险因素，而微生物药敏试验显示对所有传统抗菌药物均耐药。进一步的药敏试验表明对头孢他啶 - 阿维巴坦、头孢洛扎 - 他唑巴坦和美罗培南 - 巴坦等广泛抗菌药物耐药。然而，所有分离株对头孢地尔均敏感，头孢地尔被认为是对包括CREs在内的耐药革兰氏阴性菌具有强大体外活性的新型抗菌药物之一，这表明其对PDR病原体具有潜在治疗作用。扩展的基因组研究揭示了多个抗菌耐药基因（ARGs），包括[具体基因未提及]和[具体基因未提及]衍生类型，以及一种突变的外膜孔蛋白（OmpK37）。
