Leśniak Wiesława
Laboratory of Calcium Binding Proteins, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland.
Epigenomes. 2024 Feb 29;8(1):9. doi: 10.3390/epigenomes8010009.
Epidermis is the outer skin layer built of specialized cells called keratinocytes. Keratinocytes undergo a unique differentiation process, also known as cornification, during which their gene expression pattern, morphology and other properties change remarkably to the effect that the terminally differentiated, cornified cells can form a physical barrier, which separates the underlying tissues from the environment. Many genes encoding proteins that are important for epidermal barrier formation are located in a gene cluster called epidermal differentiation complex (EDC). Recent data provided valuable information on the dynamics of the EDC locus and the network of interactions between EDC gene promoters, enhancers and other regions, during keratinocytes differentiation. These data, together with results concerning changes in epigenetic modifications, provide a valuable insight into the mode of regulation of EDC gene expression.
表皮是由称为角质形成细胞的特殊细胞构成的皮肤外层。角质形成细胞经历一个独特的分化过程，也称为角质化，在此过程中它们的基因表达模式、形态和其他特性会发生显著变化，最终分化的角质化细胞能够形成一个物理屏障，将下层组织与环境分隔开来。许多编码对表皮屏障形成很重要的蛋白质的基因位于一个称为表皮分化复合体（EDC）的基因簇中。最近的数据提供了有关EDC基因座动态以及角质形成细胞分化过程中EDC基因启动子、增强子和其他区域之间相互作用网络的有价值信息。这些数据，连同有关表观遗传修饰变化的结果，为EDC基因表达的调控模式提供了有价值的见解。
