DNA甲基化和组蛋白修饰在系统性硬化症中的作用的最新见解：一项范围综述
Recent Insights into the Role of DNA Methylation and Histone Modifications in Systemic Sclerosis: A Scoping Review.
作者信息
Kostova Tsvetelina, Karalilova Rositsa, Batalov Zguro, Kazakova Maria, Sarafian Victoria, Batalov Anastas
机构信息
Department of Propedeutics of Internal Diseases, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Clinic of Rheumatology, UMHAT Kaspela, 4000 Plovdiv, Bulgaria.
出版信息
Diagnostics (Basel). 2024 Mar 20;14(6):652. doi: 10.3390/diagnostics14060652.
Systemic sclerosis is a complex idiopathic disease originating from an intricate interplay between genetic susceptibility, environmental factors, and epigenetic modifications. This scoping review aims to map the advancements made regarding DNA methylation abnormalities and histone modifications in systemic sclerosis in the past decade. A literature search was conducted using three electronic databases (Scopus, Web of Science and PubMed) to identify relevant articles. A total of 44 studies were selected for this review, demonstrating the critical contribution of epigenetic perturbations in multiple cell types to disease pathogenesis. In conclusion, this scoping review has elucidated the significant discoveries made in the past decade regarding the role of DNA methylation and histone modifications in systemic sclerosis. Further progress in the field could lead to the development of novel treatment possibilities targeting epigenetic marks.
系统性硬化症是一种复杂的特发性疾病，源于遗传易感性、环境因素和表观遗传修饰之间的复杂相互作用。本综述旨在梳理过去十年中系统性硬化症在DNA甲基化异常和组蛋白修饰方面取得的进展。通过使用三个电子数据库（Scopus、Web of Science和PubMed）进行文献检索，以识别相关文章。本综述共选取了44项研究，证明了多种细胞类型中的表观遗传扰动对疾病发病机制的关键作用。总之，本综述阐明了过去十年中在系统性硬化症中DNA甲基化和组蛋白修饰作用方面取得的重大发现。该领域的进一步进展可能会带来针对表观遗传标记的新型治疗方法的开发。
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