Yoo Seung Heon, Nam Ji Hyung, Oh Dong Jun, Park Geun U, Kim Sang Hoon, Kang Hyoun Woo, Kim Jae Hak, Lim Yun Jeong
Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326, Republic of Korea.
GN Co., Seoul 05051, Republic of Korea.
Diagnostics (Basel). 2024 Mar 21;14(6):666. doi: 10.3390/diagnostics14060666.
Vitamin D may have anticancer effects against colorectal cancer (CRC). Bone mineral density (BMD) reflects the long-term vitamin D status. This study investigated the association between osteoporosis and colorectal neoplasms (CRN). The data were obtained from the National Health Insurance Service sample cohort, which included 60,386 osteoporosis patients and 8224 controls who underwent BMD in 2002-2019. The logistic regression models included age, sex, income level, and comorbidity. Sensitivity tests were performed using the data from the National Health Screening Program. In total, 7706 (11.2%) patients were diagnosed with CRN, and the proportion was significantly higher in osteoporosis patients than in controls (11.7% vs. 8.1%). In the multivariate analysis, osteoporosis was associated with an increased risk of CRN (odds ratio (OR) = 1.91, 95% confidence interval = 1.75-2.09, < 0.0001), which was significant for both colorectal adenomas and CRC (OR = 1.88 and 1.83, respectively). A subgroup analysis by sex revealed a significant association between osteoporosis and CRN in both women and men (OR = 2.06 and 1.66, respectively). The sensitivity tests revealed results similar to those of the original dataset. In conclusion, osteoporosis is significantly associated with CRN risk in both sexes. In high-risk patients with low BMD, appropriate screening for CRN and vitamin D supplementation are required, regardless of sex.
维生素D可能对结直肠癌（CRC）具有抗癌作用。骨矿物质密度（BMD）反映了长期的维生素D状态。本研究调查了骨质疏松症与结直肠肿瘤（CRN）之间的关联。数据来自国民健康保险服务样本队列，其中包括2002年至2019年接受骨密度检测的60386例骨质疏松症患者和8224例对照。逻辑回归模型纳入了年龄、性别、收入水平和合并症。使用国民健康筛查计划的数据进行敏感性测试。共有7706例（11.2%）患者被诊断为CRN，骨质疏松症患者中的比例显著高于对照组（11.7%对8.1%）。在多变量分析中，骨质疏松症与CRN风险增加相关（优势比（OR）=1.91，95%置信区间=1.75 - 2.09，<0.0****01），这在结直肠腺瘤和CRC中均具有显著性（OR分别为1.88和1.83）。按性别进行的亚组分析显示，骨质疏松症与女性和男性的CRN均存在显著关联（OR分别为2.06和1.66）。敏感性测试结果与原始数据集相似。总之，骨质疏松症与两性的CRN风险均显著相关。在骨密度低的高危患者中，无论性别如何，都需要对CRN进行适当筛查并补充维生素D。
