Zhang Zhepei, Song Fengcheng, Wang Linjuan, Yuan Zhengrong
College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China.
Metabolites. 2024 Feb 21;14(3):134. doi: 10.3390/metabo14030134.
Hibernating mammals confront seasonal and harsh environmental shifts, prompting a cycle of pre-hibernation feeding and subsequent winter fasting. These adaptive practices induce diverse physiological adjustments within the animal's body. With the gut microbiota's metabolic activity being heavily reliant on the host's diet, this cycle's primary impact is on this microbial community. When the structure and composition of the gut microbiota changes, corresponding alterations in the interactions occur between these microorganisms and their host. These successive adaptations significantly contribute to the host's capacity to sustain relatively stable metabolic and immune functions in severe environmental conditions. A thorough investigation into the reciprocal interplay between the host and gut microbiota during hibernation-induced adaptive changes holds promise for unveiling new insights. Understanding the underlying mechanisms driving these interactions may potentially unlock innovative approaches to address extreme pathological conditions in humans.
冬眠的哺乳动物面临季节性和恶劣的环境变化，引发了冬眠前进食和随后冬季禁食的循环。这些适应性行为在动物体内引发了多种生理调节。由于肠道微生物群的代谢活动严重依赖宿主的饮食，这个循环的主要影响在于这个微生物群落。当肠道微生物群的结构和组成发生变化时，这些微生物与其宿主之间的相互作用也会相应改变。这些连续的适应性变化显著有助于宿主在恶劣环境条件下维持相对稳定的代谢和免疫功能。深入研究冬眠诱导的适应性变化过程中宿主与肠道微生物群之间的相互作用有望揭示新的见解。了解驱动这些相互作用的潜在机制可能会为解决人类极端病理状况开辟创新方法。
