Choi Rihwa, Lee Sang Gon, Lee Eun Hee
Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of Korea.
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
Metabolites. 2024 Mar 18;14(3):169. doi: 10.3390/metabo14030169.
Traditional lipid parameters-including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C (calculated as TC minus HDL-C)-have long been used as indicators of cardiovascular disease (CVD) risk. The laboratory records of 9604 Korean adults who underwent traditional lipid panel tests (TC, TG, and HDL), as well as ApoB testing, were analyzed to evaluate the prevalence of dyslipidemia and high CVD risk (utilizing the NCEP ATP III criteria for traditional lipid panels and various ApoB test cutoffs recommended by international guidelines (145 mg/dL, 130 mg/dL, and 100 mg/dL)). The overall prevalence of dyslipidemia, as determined by traditional lipid panel criteria, was 27.4%. Utilizing the ApoB cutoffs of 145 mg/dL, 130 mg/dL, and 100 mg/dL resulted in prevalence figures of 5.3%, 11.0%, and 36.3%, respectively. The concordance in dyslipidemia classification between traditional lipid tests and ApoB at cutoffs of 145 mg/dL, 130 mg/dL, and 100 mg/dL was 78.4%, 81.3%, and 74.7%, respectively. Up to 17.5% of participants, based on an ApoB cutoff of ≥100 mg/dL, exhibited isolated high ApoB in the absence of traditional lipid test anomalies. Incorporating ApoB testing could enhance the identification of Koreans at high CVD risk.
传统脂质参数，包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）以及非HDL-C（计算方法为TC减去HDL-C），长期以来一直被用作心血管疾病（CVD）风险指标。分析了9604名接受传统脂质检测（TC、TG和HDL）以及载脂蛋白B（ApoB）检测的韩国成年人的实验室记录，以评估血脂异常和高CVD风险的患病率（采用美国国家胆固醇教育计划成人治疗组第三次报告（NCEP ATP III）的传统脂质检测标准以及国际指南推荐的各种ApoB检测临界值（145 mg/dL、130 mg/dL和100 mg/dL））。根据传统脂质检测标准确定的血脂异常总体患病率为27.4%。采用145 mg/dL、130 mg/dL和100 mg/dL的ApoB临界值时，患病率分别为5.3%、11.0%和36.3%。在145 mg/dL、130 mg/dL和100 mg/dL的临界值下，传统脂质检测与ApoB在血脂异常分类方面的一致性分别为78.4%、81.3%和74.7%。基于≥100 mg/dL的ApoB临界值，高达17.5%的参与者在传统脂质检测无异常的情况下表现为单纯高ApoB。纳入ApoB检测可提高对高CVD风险韩国人的识别率。
