Dziadowiec Alicja, Popiolek Iwona, Kwitniewski Mateusz, Porebski Grzegorz
Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, 31-503 Krakow, Poland.
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland.
J Xenobiot. 2024 Mar 13;14(1):380-403. doi: 10.3390/jox14010024.
Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on the surface of MCs and can be targeted by multiple exogenous and endogenous ligands. It is potentially implicated in non-IgE-mediated pseudoallergic reactions and inflammatory conditions such as asthma or atopic dermatitis. In this paper, we review natural products and herbal medicines that may potentially interact with MRGPRX2. They mainly belong to the classes of polyphenols, flavonoids, coumarins, and alkaloids. Representative compounds include rosmarinic acid, liquiritin from licorice extract, osthole, and sinomenine, respectively. While evidence-based medicine studies are still required, these compounds have shown diverse effects, such as antioxidant, analgesic, anti-inflammatory, or neuroprotective. However, despite potential beneficial effects, their use is also burdened with risks of fatal reactions such as anaphylaxis. The role of MRGPRX2 in these reactions is a subject of debate. This review explores the literature on xenobiotic compounds from herbal medicines that have been shown to act as MRGPRX2 ligands, and their potential clinical significance.
肥大细胞（MCs）是存在于组织中的免疫细胞，尤其在皮肤、胃肠道和呼吸道中。近年来，人们对与Mas相关的G蛋白偶联受体X2（MRGPRX2）产生了浓厚兴趣，该受体存在于肥大细胞表面，可被多种外源性和内源性配体靶向。它可能与非IgE介导的假过敏反应以及哮喘或特应性皮炎等炎症性疾病有关。在本文中，我们综述了可能与MRGPRX2相互作用的天然产物和草药。它们主要属于多酚类、黄酮类、香豆素类和生物碱类。代表性化合物分别包括迷迭香酸、甘草提取物中的甘草苷、蛇床子素和青藤碱。虽然仍需要循证医学研究，但这些化合物已显示出多种作用，如抗氧化、镇痛、抗炎或神经保护作用。然而，尽管有潜在的有益作用，它们的使用也伴随着过敏反应等致命反应的风险。MRGPRX2在这些反应中的作用是一个有争议的话题。本综述探讨了已被证明可作为MRGPRX2配体的草药中异源生物化合物的文献及其潜在的临床意义。
