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低氧条件下进行体育活动的运动员的代谢组学和蛋白质组学分析

Metabolomic and Proteomic Profiling of Athletes Performing Physical Activity under Hypoxic Conditions.

作者信息

Malsagova Kristina A, Kopylov Arthur T, Stepanov Alexander A, Kulikova Liudmila I, Izotov Alexander A, Yurku Ksenia A, Balakin Evgenii I, Pustovoyt Vasiliy I, Kaysheva Anna L

机构信息

Institute of Biomedical Chemistry, 119121 Moscow, Russia.

Institute of Mathematical Problems of Biology RAS-The Branch of Keldysh Institute of Applied Mathematics of Russian Academy of Sciences, 142290 Pushchino, Russia.

出版信息

Sports (Basel). 2024 Mar 5;12(3):72. doi: 10.3390/sports12030072.

DOI:10.3390/sports12030072
PMID:38535735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10975304/
Abstract

Proteomic and metabolomic research enables quantitation of the molecular profile of athletes. Multiomic profiling was conducted using plasma samples collected from 18 male athletes performing aerobic activity (running) at high altitude. Metabolomic profiling detected changes in the levels of 4-hydroxyproline, methionine, oxaloacetate, and tyrosine during the recovery period. Furthermore, proteomic profiling revealed changes in expression of proteins contributing to the function of the immune system, muscle damage, metabolic fitness and performance, as well as hemostasis. Further research should focus on developing metabolic models to monitor training intensity and athlete adaptation.

摘要

蛋白质组学和代谢组学研究能够对运动员的分子概况进行定量分析。使用从18名在高海拔地区进行有氧运动（跑步）的男性运动员采集的血浆样本进行多组学分析。代谢组学分析检测到恢复期间4-羟基脯氨酸、蛋氨酸、草酰乙酸和酪氨酸水平的变化。此外，蛋白质组学分析揭示了有助于免疫系统功能、肌肉损伤、代谢适应性和表现以及止血的蛋白质表达变化。进一步的研究应侧重于开发代谢模型以监测训练强度和运动员的适应性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/6bbc08fa713a/sports-12-00072-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/775f7582b69a/sports-12-00072-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/9fbcc80e3edc/sports-12-00072-g009a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/6bbc08fa713a/sports-12-00072-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/9162cceda5da/sports-12-00072-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/c26c0fb7c718/sports-12-00072-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/0d2406a5e983/sports-12-00072-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/0cdcb955b075/sports-12-00072-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/273a8c38ffa2/sports-12-00072-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebef/10975304/775f7582b69a/sports-12-00072-g008.jpg
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