Zakošek Pipan Maja, Sterniša Meta, Plavec Tanja
Clinic for Reproduction and Large Animals, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.
Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.
Vet Sci. 2024 Mar 3;11(3):114. doi: 10.3390/vetsci11030114.
This study deals with the immunological quality of canine colostrum in relation to the different parturition modes in bitches. It included four groups of bitches, who underwent vaginal parturition (VP), emergency cesarean section (EM-CS), elective cesarean section (EL-CS), or elective cesarean section with aglepristone injection 24 h prior to surgery (EL-A). Colostrum samples from 40 bitches of 18 breeds were taken immediately after the birth of the first puppy or directly after surgery, and four hours later. The concentrations of immunoglobulin G (IgG) and IgA were measured using ELISA tests. The initial IgG concentration was 18.3 ± 10.2 g/L, and the IgA concentration was 13.7 ± 5.8 g/L, respectively. Significantly lower IgG and IgA concentrations were observed in the EL-CS group compared to other groups. The administration of aglepristone led to an increase in IgG and IgA concentrations. Despite the lower immunoglobulin levels with EL-CS, the survival rate of the puppies was not affected. The study shows that immunoglobulin concentrations in colostrum vary between bitches, with the type of birth significantly influencing the levels. Progesterone withdrawal before birth could play a decisive role in increasing IgG and IgA concentrations in the mammary glands of the bitches.
本研究探讨了母犬初乳的免疫质量与不同分娩方式之间的关系。研究包括四组母犬，分别经历了阴道分娩（VP）、紧急剖宫产（EM-CS）、择期剖宫产（EL-CS）或在手术前24小时注射阿孕瑞林的择期剖宫产（EL-A）。在第一只幼犬出生后或手术后立即，以及4小时后，采集了来自18个品种的40只母犬的初乳样本。使用酶联免疫吸附测定（ELISA）试验测量免疫球蛋白G（IgG）和IgA的浓度。初始IgG浓度分别为18.3±10.2g/L，IgA浓度为13.7±5.8g/L。与其他组相比，EL-CS组的IgG和IgA浓度显著降低。阿孕瑞林的给药导致IgG和IgA浓度增加。尽管EL-CS组的免疫球蛋白水平较低，但幼犬的存活率并未受到影响。该研究表明，初乳中的免疫球蛋白浓度在母犬之间存在差异，分娩类型对其水平有显著影响。出生前孕酮撤退可能在增加母犬乳腺中IgG和IgA浓度方面起决定性作用。
