Norwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK.
Earlham Institute, Norwich Research Park Innovation Centre, Colney Lane, Norwich NR4 7UZ, UK.
J Med Microbiol. 2024 Mar;73(3). doi: 10.1099/jmm.0.001817.
There is growing evidence that altered microbiota abundance of a range of specific anaerobic bacteria are associated with cancer, including spp., spp., spp., spp., spp., spp spp and spp. linked to multiple cancer types. In this review we explore these pathogenic associations. The mechanisms by which bacteria are known or predicted to interact with human cells are reviewed and we present an overview of the interlinked mechanisms and hypotheses of how multiple intracellular anaerobic bacterial pathogens may act together to cause host cell and tissue microenvironment changes associated with carcinogenesis and cancer cell invasion. These include combined effects on changes in cell signalling, DNA damage, cellular metabolism and immune evasion. Strategies for early detection and eradication of anaerobic cancer-associated bacterial pathogens that may prevent cancer progression are proposed.
越来越多的证据表明，一系列特定厌氧菌的微生物群落丰度的改变与癌症有关，包括与多种癌症类型相关的 spp.、 spp.、 spp.、 spp.、 spp.、 spp.、 spp. 和 spp.。在这篇综述中，我们探讨了这些致病关联。我们回顾了已知或预测细菌与人类细胞相互作用的机制，并概述了多种细胞内厌氧菌病原体如何协同作用，导致与癌变和癌细胞侵袭相关的宿主细胞和组织微环境变化的相互关联的机制和假说。这些包括对细胞信号、DNA 损伤、细胞代谢和免疫逃逸变化的综合影响。还提出了早期检测和根除可能预防癌症进展的与癌症相关的厌氧细菌病原体的策略。
