Brighton and Hove Sexual Health and Contraception Service, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
Int J STD AIDS. 2024 Jul;35(8):616-619. doi: 10.1177/09564624241242167. Epub 2024 Mar 27.
Possible resistance to recommended treatments for scabies has emerged recently. In response to anecdotal reports of a recent increase in treatment failure with permethrin, the British Association for Sexual Health and HIV (BASHH) released a statement alerting members to this.
To examine attendances and the treatment pathways for scabies cases seen at local sexual health clinics.
A case note review of scabies attendances between January 2017 and December 2023 was conducted. Data collected included patient demographics, clinical information, and scabies treatment histories. Statistical analysis was performed.
143 patients attended with scabies. The number of scabies cases did not appear to increase significantly from 2017 to 2023 ( = .09). There was significant increase in median number of treatments per case per year over time ( = .013). The number of individuals needing second-line treatments increased significantly over time (-trend < 0.001).
Individuals with scabies are requiring more treatments to clear infection. Use of ivermectin has risen in the last year suggesting that second-line treatment is increasingly needed for eradication. Whilst treatment failure may be due to non-compliance with treatment and decontamination efforts for both index and contacts, the more recent change in findings could be attributed to a fall in permethrin efficacy.
最近出现了对推荐的疥疮治疗方法产生耐药的可能性。鉴于有关扑灭司林治疗失败的传闻不断增加，英国性健康和艾滋病协会（BASHH）发布了一份声明，提醒成员注意这一点。
检查当地性健康诊所治疗疥疮病例的就诊情况和治疗途径。
对 2017 年 1 月至 2023 年 12 月期间的疥疮就诊情况进行了病历回顾。收集的数据包括患者人口统计学信息、临床信息和疥疮治疗史。进行了统计分析。
共有 143 名患者因疥疮就诊。2017 年至 2023 年期间，疥疮病例数量似乎没有明显增加（ =.09）。随着时间的推移，每个病例每年的中位数治疗次数显著增加（ =.013）。需要二线治疗的人数也随着时间的推移显著增加（-趋势<0.001）。
患有疥疮的个体需要更多的治疗来清除感染。伊维菌素的使用在过去一年中有所增加，这表明需要越来越多的二线治疗来根除感染。尽管治疗失败可能是由于不遵守治疗和对索引病例和接触者的消毒措施，但最近发现的变化可能归因于扑灭司林疗效的下降。
