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Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community.

作者信息

Aikawa Elena, Blaser Mark C, Singh Sasha A, Levine Robert A, Yacoub Magdi H

机构信息

Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital (E.A., M.C.B., S.A.S.), Harvard Medical School, Boston.

Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital (E.A.), Harvard Medical School, Boston.

出版信息

Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):763-767. doi: 10.1161/ATVBAHA.123.319563. Epub 2024 Mar 27.

DOI:10.1161/ATVBAHA.123.319563

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10977651/

Abstract

摘要

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引用本文的文献

[1]

Recent Advances in Deciphering Normal and Diseased Aortic Valve Biology Using Transcriptomic Technologies.

J Cell Mol Med. 2025-9

[2]

Calcific aortic stenosis: omics-based target discovery and therapy development.

Eur Heart J. 2025-2-14

本文引用的文献

[1]

Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.

Sci Adv. 2024-3

[2]

Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.

Circulation. 2024-1-30

[3]

Multiscale structure and function of the aortic valve apparatus.

Physiol Rev. 2024-10-1

[4]

Bicuspid aortic valve: long-term morbidity and mortality.

Eur Heart J. 2023-11-14

[5]

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.

Circulation. 2023-8-22

[6]

Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse.

Circ Cardiovasc Imaging. 2023-4

[7]

Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.

Circulation. 2023-3-21

[8]

Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.

Eur Heart J. 2023-3-7

[9]

Bioprosthetic heart valve structural degeneration associated with metabolic syndrome: Mitigation with polyoxazoline modification.

Proc Natl Acad Sci U S A. 2023-1-3

[10]

Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel.

J Am Coll Cardiol. 2022-12-13

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