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Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community.

作者信息

Aikawa Elena, Blaser Mark C, Singh Sasha A, Levine Robert A, Yacoub Magdi H

机构信息

Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital (E.A., M.C.B., S.A.S.), Harvard Medical School, Boston.

Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital (E.A.), Harvard Medical School, Boston.

出版信息

Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):763-767. doi: 10.1161/ATVBAHA.123.319563. Epub 2024 Mar 27.

DOI:10.1161/ATVBAHA.123.319563
PMID:38536897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10977651/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a2/10977651/f395ae80548f/nihms-1968785-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a2/10977651/5651d5578df9/nihms-1968785-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a2/10977651/f395ae80548f/nihms-1968785-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a2/10977651/5651d5578df9/nihms-1968785-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a2/10977651/f395ae80548f/nihms-1968785-f0002.jpg

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Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.三维生物打印主动脉瓣阵列中疾病再现的细胞内蛋白质组学和细胞外囊泡组学标志物。
Sci Adv. 2024 Mar;10(9):eadj9793. doi: 10.1126/sciadv.adj9793. Epub 2024 Feb 28.
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Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.主要促成因子超家族结构域包含物 5 的抑制作用可减少心脏瓣膜病中脂蛋白(a)的摄取和钙化。
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主动脉瓣装置的多尺度结构与功能
Physiol Rev. 2024 Oct 1;104(4):1487-1532. doi: 10.1152/physrev.00038.2022. Epub 2023 Sep 21.
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Bicuspid aortic valve: long-term morbidity and mortality.二叶式主动脉瓣:长期发病率和死亡率。
Eur Heart J. 2023 Nov 14;44(43):4549-4562. doi: 10.1093/eurheartj/ehad477.
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Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.组织细胞外囊泡的多组学分析鉴定动脉粥样硬化和钙化性主动脉瓣狭窄的独特调节因子。
Circulation. 2023 Aug 22;148(8):661-678. doi: 10.1161/CIRCULATIONAHA.122.063402. Epub 2023 Jul 10.
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Circ Cardiovasc Imaging. 2023 Apr;16(4):e014963. doi: 10.1161/CIRCIMAGING.122.014963. Epub 2023 Apr 18.
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