[新冠疫苗在阿根廷布宜诺斯艾利斯市医护人员中的有效性和安全性。]
[Effectiveness and safety of COVID-19 vaccines in healthcare workers in Buenos Aires City, Argentina.].
作者信息
Pagotto Vanina, Seoane Facundo, Arrigo Diego, Ardiles Victoria, Asprea Valeria, De Florio Florencia, Ferloni Analia, Aliperti Valeria
机构信息
Hospital Italiano de Buenos Aires.
出版信息
Rev Fac Cien Med Univ Nac Cordoba. 2024 Mar 27;81(1):115-127. doi: 10.31053/1853.0605.v81.n1.41155.
INTRODUCTION
COVID-19 vaccination aids pandemic limitation. In Argentina, three vaccines are approved, and healthcare workers are priorized (HCWs). The aim was to determine the effectiveness of COVID-19 vaccines, analyzing change in Immunoglobulin G levels and the incidence of new COVID-19 cases up to 12 months after the second dose.
METHODS
Prospective cohort of HCWs between March 2021- 2022. COVIDAR IgG test was used to measure antibodies. A mixed-effects model was employed to compare the levels of immunoglobulin G at different time points, Kaplan Meier was used to estimate incident COVID-19 cases.
RESULTS
82 participants were included Adverse events were frequent but mild. All participant showed positive antibody at 12 months. Antibodies levels showed an increase one year after 2nd dose. Sinopharm took a long time to yield positive results. More than half of the people had mild COVID-19 disease.
CONCLUSION
COVID-19 vaccines are safe and effective.
引言
新冠病毒疫苗接种有助于控制疫情。在阿根廷，有三种疫苗获得批准，医护人员享有优先接种权。目的是确定新冠病毒疫苗的有效性，分析第二剂接种后长达12个月时免疫球蛋白G水平的变化以及新冠病毒新发病例的发生率。
方法
2021年3月至2022年期间对医护人员进行前瞻性队列研究。使用COVIDAR IgG检测来测量抗体。采用混合效应模型比较不同时间点的免疫球蛋白G水平，使用Kaplan Meier法估计新冠病毒新发病例。
结果
纳入82名参与者。不良事件常见但症状轻微。所有参与者在12个月时抗体均呈阳性。第二剂接种一年后抗体水平有所上升。国药疫苗产生阳性结果所需时间较长。超过半数的人感染过轻症新冠病毒疾病。
结论
新冠病毒疫苗安全有效。
Zotero 插件