Department of Pharmaceutical Microbiology and Microbiological Diagnostics, Medical University of Lodz, Lodz, Poland.
Department of Oncobiology and Epigenetics, University of Lodz, Lodz, Poland.
Microbiol Res. 2024 Jun;283:127703. doi: 10.1016/j.micres.2024.127703. Epub 2024 Mar 24.
Staphylococci are responsible for many infections in humans, starting with skin and soft tissue infections and finishing with invasive diseases such as endocarditis, sepsis and pneumonia, which lead to high mortality. Patients with sepsis often demonstrate activated clotting pathways, decreased levels of anticoagulants, decreased fibrinolysis, activated endothelial surfaces and activated platelets. This results in disseminated intravascular coagulation and formation of a microthrombus, which can lead to a multiorgan failure. This review describes various staphylococcal virulence factors that contribute to vascular thrombosis, including deep vein thrombosis in infected patients. The article presents mechanisms of action of different factors released by bacteria in various host defense lines, which in turn can lead to formation of blood clots in the vessels.
葡萄球菌是人类许多感染的罪魁祸首，从皮肤和软组织感染开始，最后发展为侵袭性疾病，如心内膜炎、败血症和肺炎，这些疾病导致高死亡率。败血症患者常表现出凝血途径激活、抗凝剂水平降低、纤维蛋白溶解减少、内皮表面和血小板激活。这导致弥散性血管内凝血和微血栓形成，可导致多器官衰竭。本文描述了导致血管血栓形成的各种葡萄球菌毒力因子，包括感染患者的深静脉血栓形成。本文介绍了细菌在不同宿主防御线释放的不同因子的作用机制，这些机制反过来又会导致血管内血栓形成。
