Jining Medical University, 133 Hehua Road, Jining 272067, China.
Sex Health. 2024 Mar;21. doi: 10.1071/SH23191.
Coronavirus disease 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains an ongoing global public health challenge. This disease causes damage not only to the respiratory system, affecting the normal physiological function of the lungs, but also to other vital organs, such as the heart and testicles. Existing studies have shown that co-expression of angiotensin-converting enzyme 2 and transmembrane serine protease 2 is the main mechanism by which SARS-CoV-2 invades host cells. Angiotensin-converting enzyme 2-expressing cells are widespread in the corpus cavernosum, reproductive tract and testis of men, which has raised concerns. Furthermore, abnormal sex hormone levels and decreased semen parameters were observed in coronavirus disease 2019 patients. This study comprehensively assessed the effects of SARS-CoV-2 infection on the testis, semen parameters, sex hormone levels and erectile function, and discussed possible transmission routes during sexual intercourse and the effect of vaccination on male fertility.
新型冠状病毒病 2019 是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的，仍然是一个持续存在的全球公共卫生挑战。这种疾病不仅会损害呼吸系统，影响肺部的正常生理功能，还会损害其他重要器官，如心脏和睾丸。现有研究表明，血管紧张素转换酶 2 和跨膜丝氨酸蛋白酶 2 的共表达是 SARS-CoV-2 入侵宿主细胞的主要机制。血管紧张素转换酶 2 表达细胞广泛存在于男性的海绵体、生殖道和睾丸中，这引起了人们的关注。此外，在新型冠状病毒病 2019 患者中观察到性激素水平异常和精液参数下降。本研究全面评估了 SARS-CoV-2 感染对睾丸、精液参数、性激素水平和勃起功能的影响，并讨论了性传播途径以及疫苗接种对男性生育力的影响。
