Liang C, Wei W
Department of Brucellosis, HulunBuir People's Hospital, HulunBuir 021008, China.
Occupational Health Section, HulunBuir Center for Disease Control and Prevention, HulunBuir 021008, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2024 Mar 20;42(3):195-198. doi: 10.3760/cma.j.cn121094-20230309-00070.
To analyze the epidemiological characteristics and clinical data of acute and chronic occupational brucellosis patients in order to provide a scientific basis for the prevention and treatment of occupational brucellosis. In October 2022, a study was conducted on 129 patients diagnosed with occupational brucellosis by HulunBuir Center for Disease Control and Prevention from January 2016 to December 2021. The epidemiological characteristics, clinical features, and laboratory test results of patients in the acute and chronic phases were compared and analyzed using chi-square test and student's test. The acute phase patients included 38 men and 4 women with an average age of (36.6±8.4) years old; the chronic phase patients included 73 men and 14 women with an average age of (38.4±7.9) years old. There were no significant differences in gender and age between the two groups (>0.05). The patients had a clear history of occupational exposure, and the proportion of veterinarians in acute stage (21 cases, 50.0%) was significantly higher than that in chronic stage (25 cases, 28.7%), the difference was statistically significant (<0.05). The symptoms of fever and loss of appetite in acute phase of occupational brucellosis were significantly higher than those in chronic phase, and the symptoms of fatigue and joint muscle pain were significantly lower than those in chronic phase, with statistical significances (<0.05). The increase of alanine aminotransferase, aspartate aminotransferase, C-reactive protein, erythrocyte sedimentation rate and positive rate of blood culture in acute stage were significantly higher than those in chronic stage, with statistical significances (<0.05) . Occupational brucellosis patients are predominantly middle-aged men, the acute phase is characterized by fever, loss of appetite, and increased inflammatory indicators and liver enzymes, while the chronic phase is characterized by symptoms such as fatigue and joint muscle pain. Brucellosis related occupational exposure population should seek medical treatment as soon as possible when the above symptoms occur, timely detection and treatment of occupational diseases.
分析急、慢性职业性布鲁氏菌病患者的流行病学特征及临床资料，为职业性布鲁氏菌病的防治提供科学依据。2022年10月，对呼伦贝尔市疾病预防控制中心2016年1月至2021年12月诊断的129例职业性布鲁氏菌病患者进行研究。采用卡方检验和t检验对急、慢性期患者的流行病学特征、临床特点及实验室检查结果进行比较分析。急性期患者男38例，女4例，平均年龄（36.6±8.4）岁；慢性期患者男73例，女14例，平均年龄（38.4±7.9）岁。两组患者性别、年龄比较，差异无统计学意义（>0.05）。患者职业接触史明确，急性期兽医比例（21例，50.0%）明显高于慢性期（25例，28.7%），差异有统计学意义（<0.05）。职业性布鲁氏菌病急性期发热、食欲不振症状明显高于慢性期，乏力、关节肌肉疼痛症状明显低于慢性期，差异有统计学意义（<0.05）。急性期丙氨酸氨基转移酶、天冬氨酸氨基转移酶、C反应蛋白、红细胞沉降率升高及血培养阳性率明显高于慢性期，差异有统计学意义（<0.05）。职业性布鲁氏菌病患者以中年男性为主，急性期以发热、食欲不振、炎症指标及肝酶升高为特点，慢性期以乏力、关节肌肉疼痛等症状为特点。布鲁氏菌病相关职业暴露人群出现上述症状时应尽早就医，及时发现并治疗职业病。
