Zhang X Y, Zhang T W, Li J
School of Public Health and Management, Jiangsu Vocational College of Medicine, Yancheng 224005, China.
Key Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University; Key Laboratory of Environment and Health, Xuzhou Medical University; Engineering Research Innovation Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University; School of Public Health, Xuzhou Medical University, Xuzhou 221004, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2024 Mar 20;42(3):224-231. doi: 10.3760/cma.j.cn121094-20230119-00019.
The environmental pollution and health hazards caused by the extensive use of organophosphorus flame retardants (OPFRs) have become a problem of wide concern around the world. As a typical OPFR, 2-ethylhexyl diphenyl phosphate (EHDPP) can be detected in water, atmosphere, soil and other environmental media. It widely exists in production and life and can accumulate in organisms, causing great risks the ecosystem and human health. This paper reviews the research of EHDPP domestically and abroad, and summarizes the physicochemical properties of EHDPP and the population situation of occupational exposure, environmental exposure, and population exposure in recent years. Besides, it summarizes the toxic effects and mechanisms of EHDPP, including acute toxicity, hepatotoxicity, neurotoxicity, reproductive and developmental toxicity, and carcinogenesis effects. This paper also proposes the future direction of toxicity and health risks of EHDPP, which provides a theoretical basis for further research on environmental hazards and safety evaluation of EHDPP.
有机磷阻燃剂（OPFRs）的大量使用所造成的环境污染和健康危害已成为全球广泛关注的问题。作为一种典型的有机磷阻燃剂，磷酸二（2-乙基己基）苯酯（EHDPP）可在水、大气、土壤及其他环境介质中被检测到。它广泛存在于生产和生活中，并可在生物体内蓄积，给生态系统和人类健康带来巨大风险。本文综述了国内外对EHDPP的研究，总结了EHDPP的理化性质以及近年来职业暴露、环境暴露和人群暴露的情况。此外，还总结了EHDPP的毒性作用及机制，包括急性毒性、肝毒性、神经毒性、生殖和发育毒性以及致癌作用。本文还提出了EHDPP毒性和健康风险的未来研究方向，为进一步开展EHDPP的环境危害研究及安全性评价提供了理论依据。
