Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, 100853 Beijing, China.
Department of Gastroenterology and Hepatology, The Second Medical Center, Chinese PLA General Hospital, 100853 Beijing, China.
Front Biosci (Landmark Ed). 2024 Mar 22;29(3):127. doi: 10.31083/j.fbl2903127.
Gastric cancer (GC) stands as one of the most prevalent cancer types worldwide, holding the position of the second leading cause of cancer-related deaths. Gastric lesions represent pathological alterations to the gastric mucosa, with an elevated propensity to advance to gastric cancer. Limited research has explored the potential of stem cells in the treatment of gastric lesions.
This study aimed to explore the potential of intravenous transplantation of labeled bone marrow-derived mesenchymal stem cells (BMMSCs) to inhibit the progression of precancerous gastric lesions.
In the gastric lesion disease model group, the rat tissue exhibited noteworthy mucosal atrophy, intestinal metaplasia, dysplasia, and inflammatory cell infiltration. Following the infusion of BMMSCs, a notable decrease in gastric lesions was found, with atrophic gastritis being the sole remaining lesion, which was confirmed by morphological and histological examinations. BMMSCs that were colonized at gastric lesions could differentiate into epithelial and stromal cells, as determined by the expression of pan-keratin or vimentin. The expression of vascular endothelial growth factor was significantly elevated following BMMSC transplantation. BMMSCs could also upregulate the production of humoral immune response cytokines, including interleukin (IL)-4 and IL-10, and downregulate the production of IL-17 and interferon-gamma, which could be highly associated with the cellular immune response and inflammation severity of the lesions.
BMMSC transplantation significantly reduced inflammation and reversed gastric lesion progression.
胃癌（GC）是全球最常见的癌症类型之一，是癌症相关死亡的第二大主要原因。胃病变代表胃黏膜的病理性改变，有进展为胃癌的倾向。目前，关于干细胞在胃病变治疗中的应用潜力的研究还很有限。
本研究旨在探讨静脉移植标记的骨髓间充质干细胞（BMMSCs）抑制癌前胃病变进展的潜力。
在胃病变疾病模型组中，大鼠组织表现出明显的黏膜萎缩、肠上皮化生、异型增生和炎症细胞浸润。BMMSCs 输注后，胃病变明显减少，仅残留萎缩性胃炎病变，形态学和组织学检查证实了这一点。BMMSCs 在胃病变处定植后可分化为上皮细胞和间质细胞，通过表达广谱角蛋白或波形蛋白来确定。BMMSC 移植后血管内皮生长因子的表达显著升高。BMMSCs 还可以上调体液免疫反应细胞因子，如白细胞介素（IL）-4 和 IL-10 的产生，下调 IL-17 和干扰素-γ的产生，这与病变的细胞免疫反应和炎症严重程度高度相关。
BMMSC 移植显著减轻了炎症反应，逆转了胃病变的进展。
