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[脊髓电刺激联合神经生理监测治疗高危糖尿病足]

[Spinal cord electrical stimulation with neurophysiological monitoring for treatment of high-risk diabetic foot].

作者信息

Li Zhitao, Li Wenhan, Yin Shaoya, Liu Baolong, Qin Nan, Liu Xin

机构信息

Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300350, China.

Department of Ultrasound, Tianjin Huanhu Hospital, Tianjin 300350, China.

出版信息

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2024 Mar;36(3):298-302. doi: 10.3760/cma.j.cn121430-20240118-00060.

DOI:10.3760/cma.j.cn121430-20240118-00060
PMID:38538360
Abstract

OBJECTIVE

To evaluate the clinical efficacy of a single-session implantation of spinal cord electrical stimulation with neurophysiological monitoring a spinal cord electrical stimulator under general anesthesia with neurophysiological monitoring for the treatment of high-risk diabetic foot.

METHODS

The clinical data of seven patients with high-risk diabetic foot who underwent spinal cord electrical stimulation in neurosurgery ward nine of Tianjin Huanhu Hospital from May 2022 to May 2023 were collected. The operation was performed under general anesthesia with the "C" arm X ray machine guidance and neurophysiological monitoring. The arterial diameter and peak flow rate of lower extremity, lower extremity skin temperature (calf skin temperature, foot skin temperature), visual analog scale (VAS), continuous distance of movement, blood glucose level and toe wound were compared between patients before and after surgery.

RESULTS

A total of seven patients with high-risk diabetic foot were included. The diameters and peak flow rates of femoral artery, popliteal artery, anterior tibial artery, posterior tibial artery and dorsal foot artery in both lower limbs were significantly improved after surgery. All patients had different degrees of lower limb pain before operation. After operation, VAS score decreased significantly (1.1±0.9 vs. 6.8±3.4), the pain was significantly relieved, and the calf skin temperature and foot skin temperature were significantly higher than those before surgery [calf skin temperature (centigrade): 33.3±0.9 vs. 30.9±0.7, foot skin temperature (centigrade): 31.4±0.8 vs. 29.1±0.6], fasting blood glucose and postprandial blood glucose were significantly lower than those before surgery [fasting blood glucose (mmol/L): 7.6±1.4 vs. 10.5±1.2, postprandial blood glucose (mmol/L): 9.3±2.3 vs. 13.5±1.1], the differences were statistically significant (all P < 0.01). The lower limb movement of all seven patients was significantly improved after surgery, including one patient who needed wheelchair travel before surgery, and one patient who had intermittent claudication before surgery. Among them, one patient needed wheelchair travel and one patient had intermittent claudication before surgery. All patients could walk normally at 2 weeks after operation. Among the seven patients, two patients had the diabetic foot wound ulceration before surgery, which could not heal for a long time. One month after surgery, blood flow around the foot wound recovered and the healing was accelerated. The wound was dry and crusted around the wound, and the wound healed well.

CONCLUSIONS

For diabetic high-risk foot patients who are intolerant to diabetic peripheral neuralgia and local anesthesia spinal cord electrical stimulation test, one-time implantation of spinal cord electrical stimulator under general anesthesia under neurophysiological monitoring can effectively alleviate peripheral neuralgia and other diabetic foot related symptoms, improve lower limb blood supply, and reduce the risk of toe amputation. Clinical practice has proved the effectiveness of this technique, especially for the early treatment of diabetic high-risk foot patients.

摘要

目的

评估在全身麻醉下进行脊髓电刺激器单节段植入并进行神经生理监测治疗高危糖尿病足的临床疗效。

方法

收集2022年5月至2023年5月在天津环湖医院神经外科九病区接受脊髓电刺激治疗的7例高危糖尿病足患者的临床资料。手术在全身麻醉下,在“C”形臂X线机引导及神经生理监测下进行。比较患者手术前后下肢动脉直径、峰值流速、下肢皮肤温度(小腿皮肤温度、足部皮肤温度)、视觉模拟评分(VAS)、连续行走距离、血糖水平及趾部伤口情况。

结果

共纳入7例高危糖尿病足患者。术后双下肢股动脉、腘动脉、胫前动脉、胫后动脉及足背动脉的直径及峰值流速均显著改善。所有患者术前均有不同程度的下肢疼痛。术后VAS评分显著降低(1.1±0.9 vs. 6.8±3.4),疼痛明显缓解,小腿皮肤温度和足部皮肤温度显著高于术前[小腿皮肤温度(摄氏度):33.3±0.9 vs. 30.9±0.7,足部皮肤温度(摄氏度):31.4±0.8 vs. 29.1±0.6],空腹血糖和餐后血糖显著低于术前[空腹血糖(mmol/L):7.6±1.4 vs. 10.5±1.2,餐后血糖(mmol/L):9.3±2.3 vs. 13.5±1.1],差异均有统计学意义(均P<0.01)。7例患者术后下肢运动均显著改善,其中1例术前需轮椅出行,1例术前有间歇性跛行。术后2周时所有患者均能正常行走。7例患者中,2例术前有糖尿病足伤口溃疡,长期不愈合。术后1个月,足部伤口周围血流恢复,愈合加速。伤口周围干燥结痂,愈合良好。

结论

对于不能耐受糖尿病周围神经痛及局部麻醉脊髓电刺激试验的糖尿病高危足患者,在神经生理监测下全身麻醉一次性植入脊髓电刺激器可有效缓解周围神经痛等糖尿病足相关症状,改善下肢血供,降低趾部截肢风险。临床实践证明了该技术的有效性,尤其适用于糖尿病高危足患者的早期治疗。

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