脂质纳米盘在膜蛋白结构测定中的局限性。
Limitations in membrane protein structure determination by lipid nanodiscs.
机构信息
Department of Biochemistry and Molecular Biology, University of Florida, College of Medicine, Gainesville, FL 32611, USA.
出版信息
Trends Biochem Sci. 2024 Jun;49(6):475-476. doi: 10.1016/j.tibs.2024.03.010. Epub 2024 Mar 26.
PMID:38538407
Abstract
Lipid nanodiscs are popular mimetics of biological membranes for determining membrane protein structures. However, a recent study revealed that the choice of nanodisc scaffold directly influenced the structure of an ion channel. This finding prompts us to be cautious and calls for improved membrane mimetics for structure determination.
摘要
脂质纳米盘是用于确定膜蛋白结构的生物膜的流行模拟物。然而，最近的一项研究表明，纳米盘支架的选择直接影响离子通道的结构。这一发现促使我们保持谨慎，并呼吁开发改进的膜模拟物以进行结构确定。
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