用于研究膜蛋白的纳米盘。
Nanodiscs for the study of membrane proteins.
机构信息
Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA.
Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA.
出版信息
Curr Opin Struct Biol. 2024 Aug;87:102844. doi: 10.1016/j.sbi.2024.102844. Epub 2024 May 24.
Abstract
Nanodiscs represent a versatile tool for studies of membrane proteins and protein-membrane interactions under native-like conditions. Multiple variations of the Nanodisc platform, as well as new experimental methods, have been recently developed to understand various aspects of structure, dynamics and functional properties of systems involved in signaling, transport, blood coagulation and many other critically important processes. In this mini-review, we focus on some of these exciting recent developments that utilize the Nanodisc platform.
摘要
纳米盘是一种非常有用的工具，可用于在类似天然的条件下研究膜蛋白和蛋白-膜相互作用。最近开发了多种纳米盘平台变体以及新的实验方法，以了解信号转导、物质运输、血液凝固和许多其他关键重要过程中所涉及的系统的结构、动态和功能特性的各个方面。在这篇简评中，我们重点介绍了利用纳米盘平台的一些令人兴奋的最新进展。
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