Department of Chemical & Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19103, USA.
Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Trends Cell Biol. 2024 Jun;34(6):434-436. doi: 10.1016/j.tcb.2024.03.004. Epub 2024 Mar 27.
Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.
乳腺密度是乳腺癌的一个既定风险因素。在最近的一项研究中，Northey 等人揭示了与组织硬度增加相关的细胞外信号调节激酶 (ERK) 活性的升高，促进了孕激素受体依赖性核因子 κβ 受体激活剂 (RANK) 信号传导。因此，硬度改变了激素信号的背景，并增加了乳腺干细胞。该机制为乳腺癌的潜在治疗方法提供了思路。
