School of Biology and Environmental Science, University College Dublin, D4, Dublin, Ireland.
Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Bellaterra, 08193, Spain.
New Phytol. 2024 Jun;242(5):1865-1875. doi: 10.1111/nph.19709. Epub 2024 Mar 27.
Programmed cell death (PCD) is fundamentally important for plant development, abiotic stress responses and immunity, but our understanding of its regulation remains fragmented. Building a stronger research community is required to accelerate progress in this area through knowledge exchange and constructive debate. In this Viewpoint, we aim to initiate a collective effort to integrate data across a diverse set of experimental models to facilitate characterisation of the fundamental mechanisms underlying plant PCD and ultimately aid the development of a new plant cell death classification system in the future. We also put forward our vision for the next decade of plant PCD research stemming from discussions held during the 31 New Phytologist workshop, 'The Life and Death Decisions of Plant Cells' that took place at University College Dublin in Ireland (14-15 June 2023). We convey the key areas of significant progress and possible future research directions identified, including resolving the spatiotemporal control of cell death, isolation of its molecular and genetic regulators, and harnessing technical advances for studying PCD events in plants. Further, we review the breadth of potential impacts of plant PCD research and highlight the promising new applications of findings from this dynamically evolving field.
程序性细胞死亡(PCD)对植物发育、非生物胁迫响应和免疫至关重要,但我们对其调控机制的理解仍然很零散。需要建立一个更强大的研究社区,通过知识交流和建设性的辩论来加速这一领域的进展。在本观点中,我们旨在发起一项集体努力,整合来自各种实验模型的数据集,以促进对植物 PCD 基本机制的特征描述,并最终有助于未来开发新的植物细胞死亡分类系统。我们还提出了我们对未来十年植物 PCD 研究的展望,这是基于在爱尔兰都柏林大学学院举行的第 31 届《新植物学家》研讨会“植物细胞的生死决策”(2023 年 6 月 14-15 日)期间的讨论。我们传达了已确定的重大进展和未来可能的研究方向的关键领域,包括解决细胞死亡的时空控制、分离其分子和遗传调节剂,以及利用技术进步来研究植物中的 PCD 事件。此外,我们回顾了植物 PCD 研究的广泛潜在影响,并强调了这一快速发展领域的有前途的新应用。