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微藻脂质提取物对成纤维细胞的再生代谢效率比较

Comparison of the Regenerative Metabolic Efficiency of Lipid Extracts from Microalgae and on Fibroblasts.

作者信息

Stasiewicz Anna, Conde Tiago, Domingues Maria do Rosario, Domingues Pedro, Biernacki Michał, Skrzydlewska Elżbieta

机构信息

Department of Analytical Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-069 Bialystok, Poland.

Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal.

出版信息

Antioxidants (Basel). 2024 Feb 24;13(3):276. doi: 10.3390/antiox13030276.

DOI:10.3390/antiox13030276
PMID:38539810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10967502/
Abstract

UVA radiation leads to oxidative stress and inflammation in skin cells. Therefore, the aim of this study was to compare the effect of lipid extracts from microalgae () (marine) and () (freshwater) on the redox balance and PUFA metabolism in human skin fibroblasts modified by UVA. Lipid extracts from both types of microalgae introduced into the fibroblast medium after UVA irradiation significantly reduced the level of ROS and enhanced expression of Nrf2, which increased the activity/level of antioxidants (SOD1/2, CAT, GSH, Trx). The reduction in oxidative stress was accompanied by a decrease in the level of 4-HNE, its protein adducts and protein carbonyl groups. Microalgae also reduced the activity of COX1/2, FAAH and MAGL increased by UVA, and as a consequence, the level of lipid mediators (especially after ) decreased, both from the group of endocannabinoids (AEA, 2-AG, PEA) and eicosanoids (PGE2, 15d-PGJ2, TXB2, 15-HETE), acting mainly through receptors related to G protein, the expression of which increases after UVA. This further contributed to the reduction in oxidative stress and pro-inflammatory signaling at NF-κB and TNFα levels. Therefore, it is suggested that lipid extracts from both and microalgae can be used to regenerate fibroblast metabolism disturbed by UVA radiation.

摘要

紫外线A辐射会导致皮肤细胞产生氧化应激和炎症。因此，本研究的目的是比较微藻（海洋微藻）和（淡水微藻）的脂质提取物对经紫外线A处理的人皮肤成纤维细胞氧化还原平衡和多不饱和脂肪酸代谢的影响。在紫外线A照射后将两种微藻的脂质提取物引入成纤维细胞培养基中，可显著降低活性氧水平并增强核因子E2相关因子2（Nrf2）的表达，从而提高抗氧化剂（超氧化物歧化酶1/2、过氧化氢酶、谷胱甘肽、硫氧还蛋白）的活性/水平。氧化应激的降低伴随着4-羟基壬烯醛水平、其蛋白质加合物和蛋白质羰基基团的减少。微藻还降低了经紫外线A诱导升高的环氧化酶1/2、脂肪酸酰胺水解酶和单酰甘油脂肪酶的活性，结果，脂质介质（尤其是处理后）的水平降低，这些脂质介质包括内源性大麻素（花生四烯乙醇胺、2-花生四烯酸甘油、棕榈酰乙醇胺）和类二十烷酸（前列腺素E2、15-脱氧-Δ12,14-前列腺素J2、血栓素B2、15-羟基二十碳四烯酸），它们主要通过与G蛋白相关的受体发挥作用，紫外线A照射后这些受体的表达会增加。这进一步有助于降低核因子κB和肿瘤坏死因子α水平的氧化应激和促炎信号。因此，建议海洋微藻和淡水微藻的脂质提取物可用于恢复受紫外线A辐射干扰的成纤维细胞代谢。

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