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DSS诱导的结肠炎的潜在植物疗法：用一种新的大豆品种——大红改善活性氧介导的坏死性凋亡和肠道菌群失调

Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Bunge Variety-Daehong.

作者信息

Lee Kang-In, Jo Yousang, Yuk Heung Joo, Kim Sun-Young, Kim Hyungjun, Kim Hye Jin, Hwang Soo-Keol, Park Ki-Sun

机构信息

KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.

College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.

出版信息

Antioxidants (Basel). 2024 Mar 12;13(3):340. doi: 10.3390/antiox13030340.

DOI:10.3390/antiox13030340
PMID:38539873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10968080/
Abstract

Developing new plant varieties plays a crucial role in competitiveness in the agricultural and food industries and enhancing food security. Daehong (DH) is a new variety of Bunge (CP); however, its physiological functions and potential as a nutraceutical ingredient remain unknown. Here, the efficacy of DH on inflammatory bowel disease (IBD) was investigated using dextran sulfate sodium (DSS)-induced colitis mice, and its relative pharmacological effects were analyzed against CP. DH improved colitis-induced weight loss, colon shortening, and inflammatory responses and reduced intestinal permeability. The reactive oxygen species (ROS)-mediated necroptotic signal that triggers enterocyte cell death in DSS-induced colitis was effectively controlled by DH, attributed to epicatechin. DSS-induced gut dysbiosis was recovered into a healthy gut microbiome environment by DH, increasing beneficial bacteria, like , and changing harmful bacteria, including and Peptostreptococcaceae. DH shows potential as a dietary or pharmaceutical ingredient to promote gut health and to prevent and treat IBD.

摘要

开发新植物品种在农业和食品行业的竞争力以及增强粮食安全方面发挥着关键作用。大红（DH）是一种新的葛根品种；然而，其生理功能和作为营养保健成分的潜力仍不为人知。在此，使用葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠研究了DH对炎症性肠病（IBD）的疗效，并分析了其相对于葛根的相关药理作用。DH改善了结肠炎诱导的体重减轻、结肠缩短和炎症反应，并降低了肠道通透性。DH有效控制了DSS诱导的结肠炎中触发肠上皮细胞死亡的活性氧（ROS）介导的坏死性凋亡信号，这归因于表儿茶素。DH将DSS诱导的肠道菌群失调恢复到健康的肠道微生物群环境，增加了有益细菌，如， 并改变了有害细菌，包括和消化链球菌科。DH显示出作为促进肠道健康以及预防和治疗IBD的膳食或药物成分的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/a9c02808870e/antioxidants-13-00340-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/116c8681040a/antioxidants-13-00340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/b8ca8b82d5df/antioxidants-13-00340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/57ec05c0077d/antioxidants-13-00340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/040c98bf08d2/antioxidants-13-00340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/32901353096f/antioxidants-13-00340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/a9c02808870e/antioxidants-13-00340-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/116c8681040a/antioxidants-13-00340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/b8ca8b82d5df/antioxidants-13-00340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/57ec05c0077d/antioxidants-13-00340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/040c98bf08d2/antioxidants-13-00340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/32901353096f/antioxidants-13-00340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8518/10968080/a9c02808870e/antioxidants-13-00340-g008.jpg

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