miRNA 作为结直肠癌早期检测的生物标志物。
miRNA as a Biomarker for the Early Detection of Colorectal Cancer.
机构信息
John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USA.
University of Hawaii Cancer Center, 01 Ilalo Street, Honolulu, HI 96813, USA.
出版信息
Genes (Basel). 2024 Mar 5;15(3):338. doi: 10.3390/genes15030338.
Abstract
MicroRNAs (miRNAs) are short, non-coding RNA segments that can be detected in a variety of clinical samples, including serum, stool, and urine. While miRNAs were initially known for their effect on post-translational gene expression, the last decade of research has shown them to be promising biomarkers for the detection of many types of cancer. This paper explores the use of miRNA detection as a tool for colorectal cancer (CRC) screening. We discuss the current state of miRNA detection, compare it to the existing CRC screening tools, and highlight the advantages and drawbacks of this approach from a clinical and logistical perspective. Our research finds that miRNA-based tests for CRC show great potential, but that widespread clinical adoption will be conditional on future research overcoming key hurdles.
摘要
微小 RNA（miRNAs）是短的、非编码的 RNA 片段，可以在多种临床样本中检测到，包括血清、粪便和尿液。尽管最初 miRNAs 因其对翻译后基因表达的影响而闻名，但过去十年的研究表明，它们是检测多种癌症的有前途的生物标志物。本文探讨了 miRNA 检测作为结直肠癌（CRC）筛查工具的应用。我们讨论了 miRNA 检测的现状，将其与现有的 CRC 筛查工具进行了比较，并从临床和后勤的角度突出了这种方法的优缺点。我们的研究发现，基于 miRNA 的 CRC 检测方法具有巨大的潜力，但广泛的临床应用将取决于未来的研究能否克服关键障碍。
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本文引用的文献
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